1. Liquid biopsy in ovarian cancer
Our research focuses on the optimization and development of liquid biopsy approaches for clinical applications in ovarian cancer, including minimal residual disease (MRD) monitoring and early detection. We are also interested in investigating the biology and clinical relevance of circulating tumor cells (CTCs), a still poorly understood component in this disease.
2. Cancer metabolism and mitochondrial targeting
We study the metabolic features of ovarian cancer, with a particular focus on targeting mitochondrial respiratory complex I. Our work explores strategies to improve the efficacy and safety of complex I–targeted therapies, as well as the immunogenic effects of OXPHOS impairment, with the aim of enhancing tumor immunogenicity and overcoming immune resistance.
3. Label-free technologies for cancer detection
In collaboration with the National Research Council (CNR), we contribute to the development of label-free approaches for cancer detection. This includes technological optimization and the integration of advanced imaging and analytical methods to improve tumor cell identification.
