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Pubblicazioni antecedenti il 2004
Pubblicazioni scientifiche del periodo: 1993 - 2003
1. Spampinato S., Paradisi R., Canossa
M., Campana G., Frank G., Flamigni C., Ferri S., Immunoreactive
Dynorphin A-like material in extracted human
hypothalamic-hypophysial plasma. Life Sciences, 52, 223-230,
1993.
2. Canossa M., Ventura C., Vaona I.,
Carboni L., Guarnieri C., Spampinato S., Prodynorphin mRNA
expression in adult cultured rat ventricular cardiac myocytes.
Biochimica et Biophysica Acta, 1172, 247-250, 1993.
3. Ventura C., Canossa M., Vaona I.,
Carboni L., Caldarera Cm., Spampinato S., Guarnieri C. Prodynorphin
mRNA is synthesized in adult cultured rat ventricular
cardiomyocytes. Cardioscience 4, 21-24, 1993.
4. Fontana S., Bernardi P., Pich E.M.,
Capelli M., Bortoluzzi L., Spampinato S., Canossa M., Relationship
between plasma Atrial Natriuretic Factor and opioid peptide levels
in healthy subjects and in patients with acute congestive heart
failure. European Heart Journal, 14, 219-225, 1993.
5. Spampinato S., Bachetti T., Carboni
L., Ratti E., Van Amsterdam F.T.M., Ferri S., Ca2+ Channel blocking
activity of lacidipine and amlodipine in A7r5 vascular smooth
muscle cells. European Journal of Pharmacology. Molecular
Pharmacology Section, 244, 139-144, 1993.
6. Ronsisvalle G., Pasquinucci L.,
Pappalardo M.S., Vittorio F., Fronza G., Romagnoli C., Pistacchio
E., Spampinato S., Ferri S., Non-peptide ligands for opioid
receptors. Design of K-specific agonists. Journal of Medicinal
Chemistry, 36, 1860-1865, 1993.
7. Berlinck R.G.S., Braekman J.C.,
Daloze D., Bruno I., Riccio R., Ferri S., Spampinato S., Speroni
E., Polycyclic guanidine alkaloids from the marine sponge Crambe
Crambe and Ca++ channel blocker activity of Crambescidin 816.
Journal of Natural Products, 56, 1007-1015, 1993.
8. Melchiorre C., Bolognesi M.L.,
Chiarini A., Minarini A., Spampinato S., Synthesis and biological
activity of some methoctramine-related tetraamines bearing A
11-Acetyl-5,11-Dihydro-6h-Pyrido[2,3-B][1,4]-Benzodiazepin-6-One
moiety as antimuscarinics: a second generation of highly selective
M2 muscarinic receptor antagonists. Journal of Medicinal Chemistry,
36, 3734-3737, 1993.
9. Spampinato S., Speroni E., Govoni P.,
Pistacchio E., Romagnoli C., Murari G., Ferri S., Effect of
w-conotoxin and verapamil on antinociceptive, behavioural and
thermoregulatory responses to opioids in the rat. European Journal
of Pharmacology, 254, 229-238, 1994.
10. Ventura C., Guarnieri C., Vaona I., Campana G., Pintus
G., Spampinato S., Dynorphin gene expression and release in the
myocardial cell. Journal of Biological Chemistry, 269, 5384-5386,
1994.
11. Flamigni F., Campana G., Carboni L., Guarnieri C.,
Spampinato S., Zinc is required for the expression of ornithine
decarboxylase in a difluoromethylornithine-resistant cell line.
Biochemistry Journal, 299, 515-519, 1994.
12. Spampinato S., Canossa M., Carboni L., Campana G.,
Leanza G., Ferri S., Inhibition of oroopiomelanocortin expression
by an Ooigodeoxynucleotide complementary to Beta-endorphin mRNA.
Proceedings of the National Academy Science Usa (PNAS), 91,
8072-8076, 1994.
13. Flamigni F., Campana G., Carboni L., Rossoni C.,
Spampinato S., Post-trascriptional inhibition of ornithine
decarboxylase induction by zinc in a difluoromethylornithine
resistant cell line. Biochimica et Biophysica Acta, 1201, 101-105,
1994.
14. Minarini A., Bolognesi M.L., Budriesi R., Canossa M.,
Chiarini A., Spampinato S., Melchiorre C., Design, Synthesys and
biological activity of methoctramine. related tetraamines bearing a
11-Acetyl-5,11-Dyhidro-6h-Pyrido[2,3-B] [1,4]-Benzodiazepin-6-One
Moiety: structural requirements for optimum occupancy of muscarinic
receptor subtypes as revealed by symmetrical and unsymmetrical
polyamines, Journal of Medicinal Chemistry, 37, 3363-3372,
1994.
15. Ronsisvalle G., Pappalardo M.S., Prezzavento O.,
Marrazzo A., Caccamese S., Carboni L., Spampinato S., e-Pmtc, an
opioid antagonist bivalent ligand based on
N-(Phenylpropyl)-Normetazocine with very high preference for
K-sites. Medicinal Chemistry Research, 4, 245-253, 1994.
16. Fontana F., Bernardi P., Merlo Pich E., Boschi S., De
Iasio R., Capelli M., Carboni L., Spampinato S., Endogenous opioid
system and Atrial Natriuretic Factor in normotensive offspring of
hypertensive parents at rest and during exercise test.
Journal Hypertension, 12, 1285-1290, 1994.
17. Minarini A., Tumiatti V., Pistacchio E., Spampinato S.
, Melchiorre C., Synthesis and biological activity of 1,4
Dihydropyridine derivatives combining calcium and a1-adrenoceptor
antagonistic properties. Medicinal Chemistry Research, 4,153-160,
1994.
18. Giammona G., Carlisi B., Cavallaro G., Pitarresi G.,
Spampinato S. A new water-soluble synthetic polymer, a,
b-Polyasparthydrazide, as a potential plasma expander and drug
carrier. Journal Controlled Release, 29,63-72,1994.
19. Spampinato S., Canossa S., Campana G., Carboni L.,
Bachetti T. Estrogen regulation of prodynorphin gene expression in
the rat adenohypophisis: effect of the anti-estrogen tamoxifen.
Endocrinology ,136, 1589-1594, 1995.
20. Melchiorre C., Minarini A., Spampinato S., Tumiatti V.
Design, synthesis and biological activity of some tetraamines
related to methoctramine and 4-Damp. Bioorganic & Medicinal
Chemistry Letters 5, 785-790, 1995.
21. Tumiatti V., Spampinato S., Recanatini M., Minarini
A., Melchiorre C., Chiarini A., Budriesi R. Design, synthesis and
biological activity of some 4-Damp-related compounds. Bioorganic
& Medicinal Chemistry Letters, 5, 2325-2330, 1995.
22. Puglisi G., Ventura A., Spadaro A., Campana G.,
Spampinato S. Differential effects of modified Beta-cyclodestrins
on pharmacologycal activity and bioavailability of 4-biphenylacetic
acid in rats after oral administration. Journal of Pharmacy and
Pharmacology, 47,120-123, 1995.
23. Melchiorre C., Minarini A., Budriesi R., Chiarini A.,
Spampinato S., Tumiatti V. The design of novel
methoctramine-related tetraamines as muscarinic receptor subtype
selective antagonists. Life Sciences, 56, 837-844,1995.
24. Ronsisvalle G., Prezzavento O., Pasquinucci L.,
Marrazzo A., Vittorio F., Gomez-Vidal J.A., Carboni L., Spampinato
S. CCB, a novel specific K opioid agonist, which discriminates
between opioid and s1 recognition sites. Life Sciences, 56,
837-844, 1995.
25. Dei S., Bellucci C., Ghelardini C., Romanelli M.N.,
Spampinato S. Synthesis, Characterization and pharmacological
profile of tropicamide enantiomers. Life Sciences 58, 2147-2153,
1996.
26. Giammona G., Pitarresi G., Tomarchio V., Spampinato
S., Govoni P., Campana, G. New hydrogel matrices based on chemical
crosslinked a, b- polyaspartazide : synthesis,
characterization and in vivo biocompatibility studies.
International Journal of Pharmaceutics 127, 165-175, 1996.
27. Santagati M., Modica M., Santagati A., Russo F.,
Spampinato S. Synthesis of Aminothienopyrimidine And
Thienotriazolopyrimidine derivatives as potential anticonvulsant
agents. Pharmazie, 51, 7-11, 1996.
28. Carboni L., Campana G., Cacciaguerra S., Speroni E.,
Murari G., Ronsisvalle G., Spampinato S. Agonist binding properties
for recombinant Kappa opioid receptors expressed in CHO-K1 cells.
Ann. N.Y. Acad. Sci. 812, 203-205, 1997.
29. Fontana F., Bernardi P., Spampinato S., Boschi S., De
Iasio R., Grossi G. Pressor effects of endogenous opioid system
during acute episodes of blood pressure increases in hypertensive
patients. Hypertension. 29, 105-110, 1997.
30. Giardinà D., Crucianelli M., Gulini U., Marucci G.,
Melchiorre C., Spampinato S. Synthesis and a1-antagonist activity
of new prazosin- and benextramine-related tetraamine disulfides.
European Journal of Medicinal Chemistry 32, 9-20, 1997.
31. Fontana F., Bernardi P., Merlo Pich E., Boschi S., De
Iasio R., Spampinato S., Grossi G. Opioid peptide modulation of
circulatory and endocrine response to mental stress in humans.
Peptides 18, 169-175, 1997.
32. Ucar H., Cacciaguerra S., Spampinato S., Van
Derpoorten K., Isa M., Kanyonyo M., Poupert J. 2(3H)-Benzoxazolone
and 2(3H)-Benzothiazolone derivatives : novel, potent and
selective s1 receptor ligands. European Journal of Pharmacology,
355, 267-273, 1997.
33. Fontana F., Bernardi P., Merlo Pich E., Boschi S., De
Iasio R., Spampinato S. Endogenous opioid peptides and mental
stress in congestive heart failure patients. Peptides, 19, 21-26,
1998.
34. Ucar H., Van Derpoorten K., Cacciaguerra S.,
Spampinato S., Stables J., Depovere P., Isa M., Masereel B.,
Delarge J., Poupert J.H. Synthesis and anticonvulsant activity of
2(3H)-Benzoxazolone and 2(3H)-Benzothiazolone derivatives. Journal
of Medicinal Chemistry, 41, 1138-1145, 1998.
35. Fresta M., Chillemi R., Spampinato S., Sciuto S.,
Puglisi G. Liposomal Delivery Of A 30-Mer antisense
oligodeoxynucleotide to inhibit proopiomelanocortin expression.
Journal of Pharmaceutical Sciences 87, 616-625, 1998.
36. Quaglia W., Giannella M., Piergentili A., Pigini N.,
Brasili L., Di Toro R., Rossetti L., Spampinato S., Melchiorre C.
1'-Benzyl-3,4-Dihydrospiro[2h-1-Benzothiopyran-2,4'-Piperidine]
(Spipethiane), a potent and highly selective s1 ligand. Journal of
Medicinal Chemistry, 41, 1557-1560, 1998.
37. Ronsisvalle G., Marrazzo A., Prezzavento O.,
Pasquinucci L., Vittorio F., Pittala' V., Pappalardo M.S.,
Cacciaguerra S., Spampinato S.
(+)-Cis-N-Ethyleneamino-N-Normetazocine derivatives. Novel and
selective s ligands with antagonist properties. Journal of
Medicinal Chemistry, 41, 1574-1580. 1998.
38. Bolognesi M.L., Minarini A., Budriesi R., Cacciaguerra
S., Chiarini A., Spampinato S., Tumiatti V., Melchiorre C.
Universal template approach to drug design: polyamines as selective
muscarinic receptor antagonists. Journal of Medicinal Chemistry,
41, 4150-4160. 1998.
39. Di Toro R. Campana G., Sciarretta V., Murari G.
Spampinato S. Regulation of delta opioid receptors by
delta-9-tetrahydrocannabinol in NG 108-15 hybrid cells. Life
Sciences 63, Pl 197-204, 1998.
40. Fontana F., Bernardi P., Merlo Pich E., Tartuferi L.,
Boschi S., De Iasio R., Spampinato S. Opioid peptides in response
to mental stress in asymptomatic dilated cardiomyopathy. Peptides,
19, 1147-1153, 1998.
41. Budriesi R., Aicardi G., Campana G., Spampinato S.,
Zaza A., Bisi A., Rampa A., Valenti P., Chiarini A. Selective
cardiodepressant activity of fluodipine, a
fluorenone-1,4-dihydropyridine derivative. European Journal of
Pharmacology, 359, 161-170, 1998.
42. Bucolo C., Campana G., Di Toro R., Cacciaguerra S.,
Spampinato S. s1 recognition sites in rabbit iris-ciliary body:
topical s1-site agonists lower intraocular pressure. Journal of
Pharmacology and Experimental Therapeutics, 289, 271-278, 1999.
43. Spampinato S., Falcucci B., Cacciaguerra S., Campana
G., Murari G. Characterization of a putative calcitonin receptor in
IMR 32 human neuroblastoma cells. Neuroscience Letters, 273,
167-170, 1999.
44. Ronsisvalle G., Pasquinucci L., Pittala' V., Marrazzo
A., Prezzavento O., Di Toro R., Falcucci B., Spampinato S.
Nonpeptide analogues of dynorphin A(1-8): design, synthesis and
pharmacological evaluation of Kappa-selective agonists. Journal of
Medicinal Chemistry 43, 2992-3004, 2000.
45. Ronsisvalle G., Marrazzo A., Prezzavento O.,
Pasquinucci L., Falcucci B., Di Toro R., Spampinato S. Substituted
1-Phenyl-2-Cyclopropylmethylamines with high affinity and
selectivity for sigma sites. Bioorganic & Medicinal Chemistry
8, 1503-1513, 2000.
46. Pasquariello A., Di Toro R., Nyberg F., Spampinato S.
Down-regulation of delta opioid receptor mRNA by an anabolic
steroid in neuronal hybrid cells. Neuroreport, 11, 863-867,
2000.
47. Di Toro R., Campana G., Murari G., Spampinato S.
Effects of specific bile acids on c-fos messenger RNA levels in
human colon carcinoma Caco-2 cells. European Journal of
Pharmaceutical Sciences, 11, 291-298, 2000.
48. Cardillo G, Gentilucci L, Melchiorre P, Spampinato S.
Synthesis and binding activity of Endomorphin-1 analogues
containing beta-amino acids. Biorgonic & Medicinal Chemistry
Lettetter 10, 2755-2758, 2000.
49. Fontana F., Bernardi P., Pich E.M., Tartuferi L.,
Boschi S., Spampinato S. Opioid peptide modulation of circulatory
response to hyperventilation in humans. Peptides 21: 1223-1230,
2000.
50. Ronsisvalle G, Prezzavento O, Marrazzo A, Vittorio F,
Bousquet E, Di Toro R, Spampinato S. Synthesis and binding affinity
of cis-(-)- and cis-(+)-N-Ethyleneamino-N-Nordeoxymetazocine and
Cis-(-)-N-Normetazocine Analogues at sigma(1), sigma(2) and Kappa
opioid receptors. European Journal of Pharmaceutical Sciences
12, 277-284, 2001.
51. Budriesi R., Cacciaguerra S., Di Toro R., Bolognesi
M.L., Chiarini A., Minarini A., Rosini M., Spampinato S., Tumiatti
V., Melchiorre C. Analysis of the muscarinic receptor subtype
mediating inhibition of the neurogenic contractions in rabbit
isolated vas deferens by a series of polymethylene tetra-amines.
British Journal of Pharmacolology 132, 1009-1016, 2001.
52. Fontana F., Bernardi P., Tartuferi L., Boschi S., Di
Toro R., Spampinato S. Opioid peptides attenuate blood pressure
increase in acute respiratory failure. Peptides 22: 631-637,
2001.
53. Spampinato S., Di Toro R., Qasem A.R.
Nociceptin-induced internalization of the ORL-1 receptor in human
neuroblastoma cells. Neuroreport 12, 3159-3163, 2001.
- Angeli P, Marucci G, Buccioni M, Piergentili A, Giannella M,
Quaglia W, Pigni M, Cantalamessa F, Nasuti C, Novi F, Maggio R,
Qasem Ar, Spampinato S. Deoxamuscaroneoxime derivatives as useful
muscarinic agonists to explore the muscarinic subsite: demox, a
modulator of orthosteric and allosteric sites at cardiac muscarinic
M-2 receptors. Life Sciences 70, 1427-1446, 2002.
- Loizzo A, Loizzo S, Lopez L, D'amore A, Renzi P, Spampinato S,
Di Carlo S, Bacosi A, Zuccaro P, Pacifici R. Naloxone prevents
cell-mediated immune alterations in adult mice following repeated
mildstress in the neonatal period. British Journal of Pharmacology
135, 1219-1226, 2002.
- Mouithys-Mickalad A, Poupaert Jh, Spampinato S, Lesieur D.
Synthesis and pharmacological evaluation of 6-piperidino- and
6-piperazinoalkyl-2(3h)-benzothiazolones as mixed sigma/5-HT1a
ligands. Bioorganic & Medicinal Chemistry Letters 12,
1149-1152, 2002.
- Fontana F, Bernardi P, Spampinato S, Di Toro R, Bugiardini R.
Beta-Endorphin modulation of pressor response to hyperventilation
in hypertensive patients. Peptides 23, 911-918, 2002.
- Santagati Na, Prezzavento O, Bousquet E, Ronsisvalle G,
Spampinato S. Synthesis and spasmolytic action of 2-substituted
thienopyrimidin-4-one derivatives. Journal of Pharmacy and
Pharmacology 54, 717-728, 2002.
- Cardillo G, Gentilucci L, Qasem Ar, Sgarzi F, Spampinato S.
Endomorphin-1 analogues containing beta-proline are mu-opioid
receptor agonists and display enhanced enzymatic hydrolysis
resistance. Journal of Medicinal Chemistry 45, 2571-2578,
2002.
- Ronsisvalle G, Prezzavento O, Marrazzo A, Vittorio F, Massimino
M, Murari G, Spampinato S. Synthesis of
(+)-cis-n-(4-isothiocyanatobenzyl)-n-normetazocine, an
isothiocyanate derivative of n-benzylnormetazocine as acylant agent
for the sigma(1) receptor. Journal of Medicinal Chemistry 45,
2662-2665, 2002.
- Spampinato S, Di Toro R, Alessandri M, Murari G.
Agonist-induced internalization and desensitization of the human
nociceptin receptor expressed in CHO cells. Cellular and Molecular
Life Sciences 59, 2172-2183, 2002.
- Campana G, Bucolo C, Murari G, Spampinato S. Ocular hypotensive
action of topical flunarizine in the rabbit: role of sigma(1)
recognition sites. Journal of Pharmacology and Experimental
Therapeutics 303, 1086-1094, 2002.
- Cardillo G, Gentilucci L, Tolomelli A, Qasem AR, Spampinato S,
Calienni M. Conformational analysis and mu-opioid receptor affinity
of short peptides, endomorphin models in a low polarity solvent.
Org Biomol Chem. 2003 Sep 7;1(17):3010-4.
- Cardillo G, Gentilucci L, Tolomelli A, Calienni M, Qasem AR,
Spampinato S. Stability against enzymatic hydrolysis of
endomorphin-1 analogues containing beta-proline. Org Biomol Chem.
2003 May 7;1(9):1498-502.
- Spampinato S, Qasem AR, Calienni M, Murari G, Gentilucci L,
Tolomelli A, Cardillo G. Antinociception by a peripherally
administered novel endomorphin-1 analogue containing beta-proline.
Eur J Pharmacol. 2003 May 23;469(1-3):89-95.
