Daria Giacomini

Prof. Daria Giacomini

Graduated in Chemistry in 1982. Grants by Tecnofarmaci "Progetto Vimi II" in 1983, and by National Academy of Lincei 1984-1986. In 1986 she took her PhD in Chemistry under the supervision of  Prof. Gianfranco Cainelli with a thesis “Total Synthesis of prostaglandins and beta-lactams”.

 Researcher at the National Council of Research from 1988 to 1990, she studied synthesis and reactivity of organometallic compounds of copper and silicon.

Research Assistant at the Department of Chemistry “G.Ciamician” University of Bologna Faculty of Science from 1990 to 2000.

Since 2000 she has been Associate Professor in Organic Chemistry in the Faculty of Science, University of Bologna.

Research topics 

1. Design and Synthesis of new beta-lactams

•  Synthesis of new beta-lactam compound designed as antibacterial agents against resistant bacteria. 
• Synthesis of new beta-lactam derivative with a dual antioxidant and antibacterial activity.        
• Design and synthesis of new antibacterial agents against Staphylococcus aureus resistant strains (MRSA and MSSA) obtaind from clinical isolates of cystic fibrosis patients.
• Synthesis of new beta-lactam compound designed as inhibitors of Human Leucocite Elastase and Thrombin
• Design and synthesis of new inhibitors with an azetidinone scaffold of histones HDAC as molecular targets for new anticancer treatments.

• Design and synthesis of new azetidinone derivatives conjugated with a carotenoid framework, evaluation as differentiative stem cells agents.

 Biocatalysis: studies on chemo-enzymatic approach to fine-chemicals.  

•  Application of alcohol dehydrogenases and Laccase in the chemoenzymatic synthesis of Profens, important class of antiinflammatory agents.
• Stereoselectivity in organic synthesis: solvent and temperature effects on enantio- and diastereoselective organic reactions. Enzymatic enantioselectivity in organic solvents on Lipases and Dehydrogenases.
• Studies in biocatalitic conversion of azetidinones.
• Synthesis of alpha-aminonitriles and their transformations.