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Anna Rita Franco Migliaccio

Professor

Department of Biomedical and Neuromotor Sciences

Academic discipline: BIO/17 Histology

Curriculum vitae

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Revised 10/04/19

CURRICULUM VITAE ET STUDIORUM

Anna Rita Franco Migliaccio

ACADEMIC APPOINTMENTS

Full Professor

“Chiara Farma”

Istologia ed Embriologia

Faculty of Medicine

University Alma Mater

Bologna, Italy 11/03/2014-present

Professor of Medicine

Tisch Cancer Institute

Mount Sinai School of Medicine 9/01/2007- 04/27/2018

New York, NY, USA

Professor of Medicine

Department of Medicine

University of Illinois at Chicago

Chicago, IL, USA 11/16/06-09/30/07

Visiting Associate Professor

Department of Pathology

University of Illinois at Chicago

Chicago, IL, USA 08/15/2005-08/15/2006

Director of Research in Transfusion Medicine

Istituto Superiore di Sanità
Rome, Italy 10/20/98-11/02/2014

Associate Member and Co-director

Laboratory of Hematopoietic Growth Factors

New York Blood Center, NY, USA 1992-1997

Associate Investigator
Istituto Superiore di Sanità
Rome, Italy 1/1/94-10/20/98

Associate Investigator

Laboratory of Hematopoietic Growth Factors

New York Blood Center, NY, USA June 1989-1992

Investigator

Istituto Superiore di Sanità
Rome, Italy 1/1/85-12/31/93

EDUCATION

PhD in Natural Science (110/110 cum laude)
University of Naples, Naples, Italy 1972-1975

PhD in Biological Science (110/110 cum laude)
University of Naples, Naples, Italy 1975-1977

Visiting scientist,

Istituto di Patologia Medica
II Policlinico di Napoli, Naples
(Supervisor Prof. C. Peschle) 1978-1981

EURATOM Fellowship in Radiobiology of the Hematopoietic System
Radiobiological Institute, TNO
Rijswijk, The Netherlands
(Supervisor Prof. G. Wagemaker) 1982-1983

EORTC fellowship in Hematology

Division of Hematology, Department of Medicine
University of Washington, Seattle, WA
(Supervisor Prof. JW. Adamson) 2/2/1987-2/8/1988

OTHER PROFESSIONAL APPOINTMENTS

Elected Positions in Scientific Society

Counselor, International Society of Experimental Hematology 1999-2001

Member, Fellowship Committee of EHA 2010-todate

Editorial Boards:

Associate Editor, Frontiers in Physiology April 2019-todate

Associate Editor, Experimental Hematology 2017-2020

Member, Experimental Hematology 2014-2017

Member, Experimental Hematology 1992-1995

Associate Editor, Frontiers in Cancer Molecular Targets Therapy 2011-todate

Guest Editor, Special Issue of “Citation Classics”,

Lead Editor, Special Issue of Stem Cell International

“Ex Vivo generated Red Blood Cells as Transfusion Product.” 2011

Member, Haematologica 2014-todate

Member, American Journal of Blood Research 2012-todate

Member, American Journal of Stem Cells 2012-todate

Member, F1000 Research 2012-todate

Member, Blood 2008-2016
Member, Blood 1996-2001 Member, Current Stem Cell Research and Therapy 2005-todate

Member, Stem Cells 2004-todate

Member, International Journal of Hematology 1994-1999


Scientific Review Committees:

Grant Review Panels for the European Committee 2001-todate

CNR-FIRB (Ministry of Science, Italy) 2002-todate

INSERM, (Paris, France) 2004-todate

The Netherlands Organization for Health Research and Development

(The Netherlands) 2005-todate

ASH, member abstract review category Red Cell and Thalasemia 2013

ASH, chairman abstract review category Red Cell and Thalasemia 2014

NIH. RFA for pilot grants for Multidisciplinary Research

Development Initiative from the Department of Medicine. 2015

NIH, Special Emphasis Panel for R01 targeting health in minorities

Italian Ministry of Health – Member of the study section. 2015

NIH, Special Emphasis Panel for Diversity K01 awards 2015

NIH, ad hoc member for the Molecular and Cellular Study Session Oct 2015

Ministry of Health, Italy, Quality control of 2014 Reviewers’ Comments 2015

NHLBI, Member of the PTG review Feb 23rd, 2016

Ministry of Health, Italy, Member, review panel for Finalized Projects March 2015

EU Marie-Curie Training grants March 2016

NIH, regular member for the Molecular and Cellular Study Session Jun 2016

EU 2020, Member of review panel for Research grants Oct 2016

EU 2020, Member of review panel for Research grants March 2018

Commissario Nazionale per il conferimento dell’Abilitazione Scientifica 2018-2020

Nazionale Bio/17

Member of “selezione 215 RUTD-A”, Unito Feb-Apr 2019

Member, review projects for the call ICPerMed Recognition, 2019

Ministero della Salute

Member, review panel of the EU projects submitted to ERAPerMed March 2019

Member, review panel of the EU projects submitted to ERAPerMed Sept 2018

Editor of project reviews for “Ricerca Finalizzata 2018”, Ministero della

Salute Jan 2019

Reviewer for research projects submitted to University of Padova and

Verona and to Singapore’s Science and Engineering Research Council 2018

Reviewer for VQR 2011-2014, CINECA 2016

ADMINISTRATIVE LEADERSHIP APPOINTMENTS

Italy

Course director/co-director (teaching)

Scientific Committee of the EHSCCA-ISS Meeting: Stem cell

therapy of inherited haematopoietic disorders: State of the art and

Future perspectives Rome, Italy May 14th, 1996

Scientific Committee of the Workshop: "Prevenzione dei Fattori di

Rischio della Salute Materno-Infantile" Rome, Italy Dec 15-19, 1997

Scientific Committee of the Workshop: “Terapia delle Malattie

ereditarie con trapianto in Utero. Necessità di una transizione

programmata dalla teoria alla pratica”, Istituto Superiore di

Sanità, Rome, Italy. Dec. 19th, 1998

Scientific Committee and local organizer of the International

Workshop: “Cell therapy in 2001”, Istituto Superiore di

Sanità Rome, Italy Oct 15-17, 2001

Scientific Committee and local organizer of the International

Workshop: “Animal models of human Hemopoiesis”, Istituto

Superiore di Sanità, Rome, Italy June 7th, 2002

Director, The stem cells: from theory to clinics, Advanced Course

of Scuola Superiore di Immunologia Ruggero Ceppellini, Naples, Italy Oct 16-20, 2003

Director, International Workshop: Molecular Control of Proliferation

and Differentiation of hemopoietic cells, Istituto Superiore di

Sanità, Rome, Italy Dec 16-17, 2005

Director, International Workshop: “Blood from Progenitors

Ex-Vivo”, Istituto Superiore di Sanità, Rome, Italy Sept 19th, 2011

Guest speaker Istituto Superiore di Sanita, Convegno; Rome, Italy,

Francesco Antonio Manzoli, LaVita, La didattica, la ricerca, Dec 9th, 2015

Scientific committee of the Workshop: “Translational Research for

Myeloproliferative Disorders: from Animal Models to Clinical Trials”,

Istituto Superiore di Sanità, Rome, Italy April 24th,2018

International

Hematopoietic Growth Factors Subcommittee, American Society of

Hematology 1996-2000

Red Cell SubCommittee, American Society of Hematology 2010-2014

Local Organizing Committee of the 25th ISEH Meeting, New York,

NY, USA. 1996

Scientific Committee, CNR-EC Practical Training Course:

“Advanced Technologies for Stem Cell Growth and Development”,

Pisa, Italy May 27th – June 7th 2002

International Scientific Committee, 32nd Annual Meeting of the

International Society of Experimental Hematology , Paris, France July 5-8, 2003

Co-Director, EU Workshop, EUrythron, The making of a red cell,

Rome, Italy, Sept 22-23, 2005

NHLBI Red Blood Cells Working Group 2014

Member of the Working Group on the road map for future research in

Transfusion Medicine of EHA 2015

Member of the Organizing RBC Working Group appointed by

NHLBI to organize the State of the Science Symposium in Transfusion

Medicine (TM); March 25th – 26th 2015

Member of Scientific Societies: Starting from

American Society for Hematology 1989- present

International Society for Experimental Hematology 1986- present

American Society of Gene Therapy 1997- present

European Hematology Association 1997- present

International Society of Stem Cell Research 2000- present

Bologna Academy of Science, Bologna, Italy 2013-present

Italian Society for anatomy and histology 2017-present

HONORS/AWARDS/PATENT

  • USA patent no: 6960473 “In vitro mass production of cells from blood” 2004
  • Canadian patent no. 2462404 “Amplification of human T cells from

    human cord blood in serum deprived culture stimulated with stem cell

    factor, interleukin-7 and interleukin-2” 2003

  • Invited by Scientific Committee of Blood Transfusion, ASH Presentation

    Anna Rita Migliaccio, Carolyn Whitsett, and Giovanni Migliaccio:

    Expansion of Red Blood Cells for Transfusion Blood (ASH Annual Meeting, Nov 2010; 116: SCI-46).

  • Golden Medal to the Scientific career from the Bologna

    Academy of Science, Bologna, Italy 2013

  • American Society of Gene Therapy, 18th Annual Meeting (ASGCT),

    Invited guest speaker of the education Session “ Emerging Field Review:

    Regenerative Medicine”, Title of Talk: The Potential of Stem Cells as an

    in Vitro Source of Red Blood Cells for Transfusion – New Orleans May 13th – 16th , 2015

  • Invited guest speaker of the Annual Meeting of the Italian Society for Transfusion Medicine and Immunotherapy (SIMTI): “Transfusion alternatives: future perspectives”May 25 2018
  • Zingariello M,Martelli F, Bosco D, Rana RA, Whitsett C, Lewandowski D, Spangrude GJ, Migliaccio AR, “Myelofibrosis-related stem cells in the spleen arise from an induction by their megakaryocytic progeny”; 2nd prize for best abstract for the 8th International Congress on Myeloproliferative Neoplasms, Myelodysplasia and Chronic Myeloid Leukemia; Nov. 5th – 6th 2015.
  • Abilitazioni all’insegnamento in territorio nazionale

Biologia Applicata; Area 05/F1 SSD BIO/13 Abilitazione Scientifica Nazionale 2012/2013, Prima Fascia, validità dal 22/01/2014 al 22/01/2020

Istologia; Area 05/H2 SSD BIO/17 Abilitazione Scientifica Nazionale 2012/2013, Prima Fascia, validità dal 10/01/2014 al 10/01/2020

Patologia Generale; Area 06/A2 SSD Med/04 Abilitazione Scientifica Nazionale 2012/2013, Prima Fascia, validità dal 08/01/2014 al 08/01/2020

GRANT AND CONTRACT SUPPORT

Present Grants:

List

Role in Project

Dates

Direct Costs

National Cancer Institute

CA108671-11-16: MPD Research Consortium, PI Ronald Hoffman

PI of Project 2

2017-2022

200,000/year

Associatione Italian Ricerca Cancro (AIRC 17608)

Role of TGF-β in the Pathogenesis of Myelofibrosis

PI

2016-2019

€100.000/year

NHLBI (5R01HL134684-02)

Generation of cultured RBCs with rare phenotypes for transfusion from sources usually discarded during regular blood donations

PI

2018-2022

$125.000/year

Novartis

PI

2019-2020

$160.997

Formation Biologics

PI

2019-2020

$97.356

Past Grants (partial list starting from 2005):

EC FP-6 Marie-Curie Research Training Network “EUrythron”

Investigator

2005-2008

€ 100.000/year

Program Projects from the Italian Ministry for Research and University (MIUR)

“Alterations of the hemangioblast in Idiopathic Myelofibrosis”

Co-PI

2006-2008

€ 50.000/year

PHARMA MAR S.A. Sociedad Unipersonal Madrid, Spain.

“Studies on the effects of Aplidin® on angiogenesis in a murine model of myelofibrosis, the GATA-1low mice”

Co-PI

2006-2008

€ 25.000/year

National Cancer Institute CA108671-01-04: MPD Research Consortium, PI: Ronald Hoffman.

PI of Project 4

2006-2010

$200.000/year

National Cancer Institute:

CA108671-05-10

MPD Research Consortium, PI: Ronald Hoffman.

PI of Project 4

2011-2016

$ 250.000/year

Anticancer League

Co-PI

2007-2009

€ 60.000/year

NY-STAR

PI

2007-2010

$167.000/year

Italian Effort on Doping.

La policitemia congenita come modello per la caratterizzazione degli effetti molecolari e clinici del trattamento cronico con EPO

Co-PI

2009-2010

€ 20.000/year

Centro Nazionale Sangue:

“La fattibilità per la produzione industriale di eritroblasti umani per transfusione”

P1

2010-2013

€ 50.000/year

Progetti di Ricerca Italia-USA

“Mouse models of myelofibrosis”

PI

2010-2012

€ 50.000/year

Associazione Italiana Ricerca Cancro:

“Mouse models of myelofibrosis”

PI

2011-2014

€ 100.000/year

NHLBI/R01 HL116329-01

“The human glucocorticoid receptor and normal and pathological terminal erythroid maturation”

PI

2012 –2016

250.000/year

Centro Nazionale Sangue

Validazione di cellule eritroidi espause in vitro da donatori rari come “reagent red cells”

PI

2013-2014

€ 50.000/year

LIST OF PUBLICATIONS

(Abstracts not included)

H-index = 36 (calculated by Scopus); 7445 total citations starting from 2013

Chapters in Books

  1. Peschle C, Migliaccio G, Migliaccio AR, Covelli A, Giuliani A, Mavilio F, Mastroberardino G. Hemoglobin switching in humans. In: Current Concepts in Erythropoiesis, Dunn, C. (Ed.). London: Wiley, 1983.
  2. Migliaccio G, Migliaccio AR. The kinetics of hematopoiesis in the human yolk sac. In: The Human Yolk Sac, Nogales, F, (Ed.). Heidelberg, Springer-Verlag, 1993; pp. 52. 70.
  3. Migliaccio G, Migliaccio AR. Serum-deprived cultures of primary hemopoietic cells. In: Culture of specialized cells. Vol.2: Culture of hemopoietic cells. Freshney RI, Pragnell IB, Freshney MG (Eds.). Wiley-Liss, 1994; pag. 81.
  4. Migliaccio AR, Migliaccio G, Adamson JW. Erythroid cells. In: Hemopoietic lineages: Regulation of cell production and development. Dexter M, Testa N, Lord B. (Eds.). New York, Marcel Dekker (Ed.), 1997 pp. 107-128.
  5. Migliaccio AR, Papayannopoulou Th. Erythropoiesis. In “Disorders of Hemoglobin, Genetics, Pathophysiology, Clinical Management. Steinberg MH, Forget BG, Higgs D, Nagel (Eds). 2001; pp 52-71.
  6. Migliaccio AR, Papayannopoulou Th. Erythropoiesis and the normal red cell. In Oxford textbook of Medicine. Warrell, Cox, Firth, Benz, (Eds). Oxford University Press, Fourth edition 2003;3:634-639.
  7. Papayannopoulou Th, Abkowitz J, D’Andrea A, Migliaccio AR. Biology of erythropoiesis, erythroid differentiation and maturation in: Hematology: Basic Principles and Practice. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, (Eds.) Elsevier, Philadelphia, PA, USA, 4th Edition, 2005; pp. 267-288.
  8. Papayannopoulou Th, Abkowitz J, D’Andrea A, Migliaccio AR. Biology of erythropoiesis, erythroid differentiation and maturation in: Hematology: Basic Principles and Practice. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, Heslop H (Eds) Elsevier, Philadelphia, PA, USA, 5th edition, 2008; pp.276-299.
  9. Papayannopoulou Th, Abkowitz J, D’Andrea A, Migliaccio AR. Biology of erythropoiesis, erythroid differentiation and maturation in: Hematology: Basic Principles and Practice. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, Heslop H (Eds) Elsevier, Philadelphia, PA, USA, 6th edition, 2010; pp.276-299.,Chapter 24th.
  10. Papayannopoulou T, Migliaccio AR, Biology of Erythropoiesis, Erythroid Differentiation, and Maturation in: Hematology: Basic Principles and Practice. Hoffman R, Furie B, Benz E, McGlave P, Silberstein LE, Shattil SJ, Churchill Livingstone Elsevier, Philadelphia, PA, 2011; pp 258-279.
  11. Migliaccio AR, Whitsett C and Migliaccio G. Red Cells from Stem Cells In; Chemistry and Biochemistry of Oxygen Therapeutics from Transfusion to Artificial Blood.Mozzarelli A, Bettati S (Eds), Wiley and Sans, Ltd Chichester, England, 2011, Vol 19, pp 19.1-19.15 (not in PubMed)
  12. Migliaccio AR, Grazzini G, Hillyer CD (Editors). Ex vivo generated red cells as transfusion products. [http://www.ncbi.nlm.nih.gov/pubmed/22570664] Stem Cells Int. 2012; 2012:615412.
  13. Migliaccio AR, Whitsett, C. Erythrocytes. 2013 In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0001128.pub2]
  14. Papayannopoulou T, Migliaccio AR; Erythropoiesis and the normal red cell; Oxford textbook of medicine 5e online; Firth J, Cox T, Warrell D; Oxford Univesity Press, Oxford, UK. 2015
  15. Migliaccio AR; Papayannopoulou, T; Cord Blood Hematopoiesis:The Road toTransplantation; Cord Blood Stem Cells Medicine. http;//dx.doi.org/10.1016/b978-0-12-407785-0.00003-7
  16. Papayannopoulou [https://www.sciencedirect.com/science/article/pii/B9780323357623000263?via%3Dihub#!] Th, [https://www.sciencedirect.com/science/article/pii/B9780323357623000263?via%3Dihub#!] AR. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation. Hematology (Seventh Ed.) 2018;297-320.e14. https://doi.org/10.1016/B978-0-323-35762-3.00026-3
  17. Migliaccio AR: Hematopoiesis and the hematopoietic stem cell. In: “Hematology, pathophysiology, Diagnosis and Treatment”; Sante Tura, Michele Cavo and Pier Luigi Zinzani Editors. Publisher: Società Editrice Esculapio, 2018.

    Peer Reviewed Journals

    A complete list of publications may be found to My Bibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/annarita.migliaccio.1/bibliograpahy/40626660/public/?sort=date&direction=ascending .

  18. Parisi G, D'Amora D, Franco AR. Pterin and ommochrome pigments in Drosophila melanogaster: phenocopy of the mutant mal from the double mutant mal v. Insect Biochem 1977;7:1.
  19. Peschle C, Migliaccio G, Migliaccio AR, Lettieri F, Russo G, Gianni AM, Ottolenghi S, Comi P, Giglioni B. Erythropoietic differentiation in humans: in vitro studies on erythroid progenitors and Hb synthesis in fetal, newborn and adult life. Exp Hemat 1980;8:153-9.
  20. Gianni AM, Comi P, Giglioni B, Ottolenghi S, Migliaccio AR, Migliaccio G, Lettieri F, Maguire YP, Peschle C. Biosynthesis of Hb in individual fetal liver bursts: gamma-chain production peaks earlier than beta-chain in the erythropoietic pathway. Exp Cell Res 1980;130:345-52.
  21. Peschle C, Migliaccio G, Covelli A, Lettieri F, Migliaccio AR, Condorelli M, Comi P, Pozzoli ML, Giglioni B, Ottolenghi S, Cappellini MD, Polli E, Gianni AM. Hemoglobin synthesis in individual bursts from normal and adult blood: all bursts and subcolonies synthesize G gamma and A gamma globin chains. Blood 1980;56:218-26.
  22. Rossi GB, Migliaccio AR, Migliaccio G, Lettieri F, Di Rosa M, Mastroberardino G, Peschle C. In vitro interactions of PGE and cAMP with murine and human erythroid precursors. Blood 1980;56:74-9.
  23. Peschle C, Migliaccio G, Lettieri F, Migliaccio AR, Ceccarelli R, Barba P, Titti F, Rossi GB. Kinetics of erythroid precursors in mice infected with the anemic or the polycythemic strain of Friend virus. Proc Natl Acad Sci USA 1980;77:2054-8.
  24. Comi P, Giglioni B, Pozzoli ML, Ottolenghi S, Gianni AM, Migliaccio AR, Migliaccio G, Lettieri F, Peschle C. Biosynthesis of globin chains in fetal liver and adult marrow cultures. Comparative analysis of individual colonies derived from early, intermediate or late erythroid progenitors. Exp Cell Res 1981;133:347-56.
  25. Peschle C, Migliaccio AR, Migliaccio G, Lettieri F, Quattrin S, Russo G, Mastroberardino G. Identification and characterization of three classes of erythroid progenitors in human fetal liver. Blood 1981;58:565-72.
  26. Peschle C, Rossi GB, Covelli A, Migliaccio G, Migliaccio AR, Mastroberardino G. The early stage of Friend virus erythroleukemias: mechanism underlying BPA-“independent” in vitro growth of BFU-E. Haematol. & Blood Transf 1983;28:403-6.
  27. Peschle C, Migliaccio AR, Migliaccio G, Russo G, Petrini M, Calandrini M, Mastroberardino G, Presta M, Gianni AM, Comi P, Giglioni B, Ottolenghi S. The embryonic fetal Hb switch in humans: studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver. Proc Natl Acad Sci USA 1984;81:2416-20.
  28. Peschle C, Mavilio F, Caré A, Migliaccio G, Migliaccio AR, Salvo G, Samoggia P, Petti S, Guerriero R, Marinucci M, Lazzaro D, Russo G, Mastroberardino G. Hemoglobin switching in human embryos: asynchrony of zeta-->alpha and epsilon-->gamma globin switches in primitive and definitive erythropoietic lineage. Nature 1985;313:235-8.
  29. Migliaccio G, Migliaccio AR, Petti S, Mavilio F, Russo G, Lazzaro D, Testa U, Marinucci M, Peschle C. Human embryonic hemopoiesis: cell kinetics underlying transition from yolk sac to liver erythropoiesis. J Clin Inv 1986;78:51.
  30. Migliaccio AR, Visser JWM. Proliferation of purified murine hemopoietic stem cells in serum-free cultures stimulated with purified stem cell activating factor. Exp Hemat 1986;14:1043-8.
  31. Comi P, Ottolenghi S, Giglioni B, Migliaccio G, Migliaccio AR, Bassano E, Amadori S, Mastroberardino G, Peschle C. Bromodeoxyuridine treatment of normal adult erythroid bursts: an in vitro model for the reactivation of human fetal globin genes. Blood 1986;68:1036-41.
  32. Migliaccio G, Migliaccio AR. Cloning of human erythroid progenitors (BFU-E) in the absence of fetal bovine serum. Brit J Hemat 1987;67:129-33.
  33. Migliaccio AR, Bruno M, Migliaccio G. Evidence for direct action of human biosynthetic (recombinant) GM-CSF on erythroid progenitors in serum free culture. Blood 1987;70: 1867-71.
  34. Migliaccio AR, Migliaccio G. Human embryonic hemopoiesis: control mechanisms underlying progenitor differentiation in vitro. Develop Biology 1988;125:127-34.
  35. Migliaccio G, Migliaccio AR, Adamson JW. In vitro differentiation of human granulocyte/macrophage and erythroid progenitors: Comparative analysis of the influence of recombinant erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serum-deprived cultures. Blood 1988;72:248-56.
  36. Migliaccio G, Migliaccio AR, Visser JWM. Synergism between erythropoietin and interleukin-3 in the induction of hemopoietic stem cell proliferation and erythroid differentiation. Blood 1988;72:944-51.
  37. Migliaccio AR, Migliaccio G, Adamson JW. Effect of recombinant hematopoietic growth factors on the proliferation of human marrow progenitor cells in serum-deprived culture. Blood 1988;72:1387-92.
  38. Migliaccio G. Migliaccio AR, Kaushansky K, Adamson JW. Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions. Exp. Hemat 1989;17:110-115.
  39. Migliaccio G, Migliaccio AR, Ruscetti, S Adamson JW. The growth of the Rauscher erythroleukemia cells is mediated by autocrine production of a factor with biological activity similar to interleukin-3. Blood 1989;73:1770-7.
  40. Migliaccio G, Migliaccio AR, Kreider B, Rovera G, Adamson JW. Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D. J Cell Biol 1989;109:833-41.
  41. Migliaccio AR, Migliaccio G, Shimada Y, Adamson JW. Direct effects of IL-4 on the in vitro differentiation and proliferation of hematopoietic progenitor cells. Biotech Therap 1989-1990;1:347-60.
  42. Migliaccio AR, Migliaccio G, Johnson G, Adamson JW, Torok-Storb B. Comparative analysis of hematopoietic growth factors released by stromal cells from normal donors and from transplanted patients. Blood 1990;75:305-12.
  43. Migliaccio AR, Beverly Torok-Storb B. Long-term marrow cultures after allogenic bone marrow transplantation. Response. Blood 1990;76:266-7.
  44. Migliaccio AR, Migliaccio G, Dale DC, Hammond WP. Hematopoietic progenitors in cyclic neutropenia: effect of granulocyte colony-stimulating factor in vivo. Blood 1990;75:1951-9.
  45. Migliaccio AR, Migliaccio G, Constantoulakis P, Stamatoyannopoulos G, Papayannopoulou T. Influence of recombinant hemopoietins and of fetal bovine serum on the globin synthetic pattern of human BFUe. Blood 1990;76:1150-7.
  46. Crotta S, Nicolis S, Ronchi A, Ottolenghi S, Ruzzi L. Shimada Y, Migliaccio AR, Migliaccio G. Progressive inactivation of the expression of an erythroid transcriptional factor in GM- and G-CSF-dependent myeloid cell lines. Nucleic Acids Research 1990;18:6863-9.
  47. Migliaccio G, Migliaccio AR, Adamson JW. The biology hematopoietic growth factors: studies in vitro under serum-deprived conditions. Exp Hemat 1990;18:1049. (Review).
  48. Migliaccio AR, Migliaccio G. The control of proliferation and differentiation of early erythroid progenitors. Biotherapy 1990;2:299. (Review).
  49. Migliaccio G, Migliaccio AR, Adamson JW. In vitro differentiation and proliferation of human hematopoietic progenitors: the effect of interleukins 1 and 6 are indirectly mediated by production of granulocyte/macrophage colony-stimulating factor and interleukin 3. Exp Hemat 1991;19:3-10.
  50. Migliaccio G, Migliaccio AR, Valinsky J, Langley K, Zsebo K, Visser JWM, Adamson JW. Stem Cell Factor (SCF) induces proliferation and differentiation of highly enriched murine hematopoietic cells. Proc Natl Acad Sci USA 1991;88:7420-4.
  51. Migliaccio G, Migliaccio AR, Druzin ML, Giardina PJV, Zsebo KM, Adamson JW. Effects of recombinant human stem cell factor (SCF) on the growth of human progenitor cells in vitro. J Cell Physiol 1991;148:503-9.
  52. Migliaccio AR, Migliaccio G, D'Andrea A, Baiocchi M, Ronchi A, Nicolis S, Ottolenghi S, Adamson JW. Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface. Proc Natl Acad Sci USA 1991;88:11086-90.
  53. Shimada Y, Migliaccio G, Ruscetti S, Adamson JW, Migliaccio AR. Expression of the interleukin-3 and granulocyte-macrophage colony-stimulating factor genes in Friend spleen focus-forming virus-induced erythroleukemia. Blood 1992;79:2423-31.
  54. Migliaccio G, Migliaccio AR, Druzin ML, Giardina PJV, Zsebo KM, Adamson JW. Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor. Blood 1992;79:2620-7.
  55. Migliaccio AR, Migliaccio G, Adamson JW, Torok-Storb B. Production of granulocyte colony-stimulating factor (G-CSF) and granulocyte/macrophage (GM)-CSF after interleukin-1-stimulation of marrow stromal cell cultures from normal or aplastic anemia donors. J Cell Physiol 1992;152:199-206.
  56. Nicolis S, Ottolenghi S, Papayannopoulou T, Komatsu N, Baiocchi M, Migliaccio G, Adamson JW, Migliaccio AR. Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7. Exp Hemat 1993;21:665-70.
  57. Shimada Y, Migliaccio G, Ralph H, Migliaccio AR. Erythropoietin-specific cell cycle progression in erythroid subclones of the IL-3-dependent cell line 32D. Blood 1993;81:935-41.
  58. Migliaccio AR, Migliaccio G, Durand B, Mancini G.C, Adamson JW. The generation of colony-forming cells (CFC) and the expansion of hematopoiesis in cultures of human cord blood cells is dependent on the presence of stem cell factor (SCF). Cytotechnology 1993;11:107-13.
  59. Migliaccio AR, Migliaccio G, Mancini G, Rataczak M, Gewirtz AM, Adamson JW. Induction of the murine "W phenotype" in long-term cultures of human cord blood cells by c-kit antisense oligomers. J Cell Physiol 1993;157:158-63.
  60. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S, Adamson JW. Transcriptional and post-transcriptional regulation of the expression of the erythropoietin receptor (EPO-R) gene in human Epo-responsive cell lines. Blood 1993;82:3760-9.
  61. Durand B, Eddleman K, Migliaccio AR, Migliaccio G, Adamson JW. Long-term generation of colony-forming cells (CFC) from CD34+ human umbilical cord blood cells. Leuk and Lymphoma 1993;11:263-73. (Review).
  62. Migliaccio AR, Baiocchi M, Durand B, Eddleman K, Migliaccio G, Adamson JW. Aspects of the biology of the neonatal hematopoietic stem cell. Stem Cells 1993;11:56-64. (Review).
  63. Barron C, Migliaccio AR, Migliaccio G, Jiang Y, Adamson JW, Ottolenghi S. Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow. Gene 1994;147:263-8.
  64. Durand B, Migliaccio G, Yee NS, Eddleman K, Huima-Byron T, Migliaccio AR, Adamson JW. Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin-3. Blood 1994;84:3667-74.
  65. Ashany D, Elkon K, Migliaccio G, Migliaccio AR. Functional characterization of early lymphoid precursor cells generated in serum-deprived culture stimulated with stem cell factor and interleukin 7 from normal and autoimmune mice. J Cell Physiol 1995;164:562-70.
  66. Rubinstein P, Dobrial L, Rosenfield RE, Adamson JW, Migliaccio G, Migliaccio AR, Taylor P, Stevens CE. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA 1995;92:10119-22.
  67. Eddleman KA, Chervenak FA, George-Siegel P, Migliaccio G, Migliaccio AR. Circulating hematopoietic stem cell populations in human fetuses: Implications for fetal gene therapy and alterations with in utero red cell transfusion. Fetal Diagnosis and Therapy 1996;11:231-40.
  68. Migliaccio G, Baiocchi M, Adamson JW, Migliaccio AR. Isolation and biological characterization of two classes of blast-cell colony-forming cells from normal murine marrow. Blood 1996;87:4091-9.
  69. Migliaccio G, Baiocchi M, Hamel N, Eddleman K, Migliaccio AR. Circulating progenitor cells in human ontogenesis: response to growth factors and replating potential. J Hemotherapy 1996;5:161-70.
  70. Cesano A, Pierson G, Visonneau S, Migliaccio AR, Santoli D. Use of a lethally irradiated major histocompatibility complex nonrestricted cytotoxic T-cell line for effective purging of marrows containing lysis-sensitive or -resistant leukemic targets. Blood 1996;87:393-403.
  71. Migliaccio AR, Vannucchi AM, Migliaccio G. Molecular control of erythroid differentiation. Int J Hemat 1996;64:1-29. (Review).
  72. Ashihara E, Vannucchi AM, Migliaccio G, Migliaccio AR.. Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells. J Cell Phys 1997;171:343-56.
  73. Moroni E, Cairns L, Ottolenghi S, Giglioni B, Ashihara E, Migliaccio G, Migliaccio AR. Expression in hematopoietic cells of GATA-1 transcripts from the alternative “Testis” promoter during development and cell differentiation. Biochem Biophys Res Comm 1997;231:299-304.
  74. Tanosaki R, Migliaccio AR. Engraftment of normal stem cells in W/Wvmice assessed by a novel quantitative PCR analysis. Brit J Hemat 1997;98:1017-25.
  75. Kogler G, Callejas J, Sorg RV, Fischer J, Migliaccio AR, Wernet P. The effect of different thawing methods, growth factor combinations and media on the ex vivo expansion of umbilical cord blood primitive and committed progenitors. Bone Marrow Transplant 1988;21:233-41.
  76. Sanchez M, Alfani E, Visconti G, Passarelli AM, Migliaccio G, Migliaccio AR. Thymus-independent T cell differentiation in vitro. Brit J Hemat 1998;103:1198-205.
  77. Kurata H, Mancini GC, Alespeiti G, Migliaccio AR, Migliaccio G. Stem cell factor induces proliferation and differentiation of fetal progenitor cells in the mouse. Brit J Haemat 1998;101:676-87.
  78. Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR, Berkowitz RL, Cabbad M, Dobrila L, Taylor P, Rosenfield RE, Stevens C. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New Engl J Med 1998;339:1565-77.
  79. Migliaccio AR, Migliaccio G. The Making of an Erythroid Cell. Molecular control of hematopoiesis. Biotherapy 1998;10:251-68. (Review).
  80. Bassini A, Zauli G, Migliaccio G, Migliaccio AR, Pascuccio M, Pierpaoli S, Guidotti L, Capitani S, Vitale M. Lineage-restricted expression of protein kinase C isoforms in hematopoiesis. Blood 1999;93:1178-88.
  81. Migliaccio AR, Carta C, Migliaccio G. In vivo expansion of purified hematopoietic stem cells transplanted in nonablated W/Wv mice. Exp Hematol 1999;27:1655-66.
  82. Vannucchi A, Linari S, Lin C-S, Koury M, Bondurant M, Migliaccio AR. Increased expression of the distal, but not of the proximal, Gata1 transcripts during differentiation of primary erythroid cells. J Cell Phys 1999:180:390-401.
  83. Vannucchi AM, Paoletti F, Linari S, Cellai C, Caporale R, Rossi Ferrini P, Migliaccio AR. Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood 2000;95:2559-68.
  84. Migliaccio AR, Adamson JW, Stevens CE, Dobrila NL, Carrier CM, Rubinstein P. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell quantity. Blood 2000;96:2717-22.
  85. Carta C, Campisi S, Migliaccio G, Migliaccio AR. Erythropoietin-dependent suppression of the expression of the b subunits of the interleukin-3 receptor during erythroid differentiation. Blood Cells Mol and Dis 2000;26:467-78.
  86. Alfani E, Migliaccio AR, Sanchez M, Passarelli AM, Migliaccio G. Characterization of the T cell receptor repertoire of neonatal T cells by RT-PCR and single strand conformation polymorphism analysis. Bone Mar Transpl 2000;26:83-9.
  87. Migliaccio AR, Bengra C, Ling J, Pi W, Li C, Zeng S, Keskintepe M, Whitney B, Sanchez M, Migliaccio G, Tuan D. Stable and unstable transgene integration sites in the human genome:extinction of the Green Fluorescent Protein transgene in K562 cells. Gene 2000:256:197-214.
  88. Vannucchi AM, Bianchi L, Cellai C, Paoletti F, Carrai V, Calzolari A, Centurione L, Lorenzini R, Carta C, Alfani E, Sanchez M, Migliaccio G, Migliaccio AR. Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their Gata-1 expression (GATA-1low mice). Blood 2001;97:3040-50.
  89. Stevens CE, Gladstone J, Taylor P, Scaradavou A, Migliaccio AR, Visser J, Dobrila L, Carrier C, Cabbad M, Wernet P, Kurtzberg J, Rubinstein P. Placental/Umbilical cord blood for unrelated bone marrow reconstitution:relevance of nucleated red blood cells. Blood 2002;100:2662-64.
  90. Vannucchi A, Bianchi L, Cellai C, Paoletti F, Rana RA, Lorenzini R, Migliaccio G, Migliaccio AR. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (Gata-1low mice). Blood 2002;100:1123-32. (Plenary Paper).
  91. Migliaccio G. Di Pietro R, Di Giacomo V, Di Baldassarre A, Migliaccio AR, Maccioni L, Galanello R, Papayannopoulou Th. In vitro mass cell production of human erythroid cells from the blood of normal donors and of thalassemic patients. Blood Cells Mol Dis 2002;28:169-80.
  92. Migliaccio AR, Migliaccio G, Di Baldassarre A, Eddleman K. Circulating hemopoietic progenitor cells in a fetus with alpha thalassemia:comparison with the cells circulating in normal and non-thalassemic anemia fetuses and implications for in utero transplantations. Bone Marrow Transplant 2002;30:75-80.
  93. Sanchez M, Alfani E, Migliaccio AR, Bonfini T, Migliaccio G. Amplification of T cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2. Bone Marrow Transplant 2003;31:713-23.
  94. Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Centurione L, Bianchi L, Vannucchi AM, Migliaccio G, Orkin SH:GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-low mouse mutant. J Exp Med 2003;197:281-96.
  95. Baiocchi M, Di Rico MC, Di Pietro R, Di Baldassarre A, Migliaccio AR. 5-Azacytidine reactivates the erythroid differentiation potential of the myeloid-restricted murine cell line 32D Ro, Exp Cell Res 2003;285:258-67.
  96. Vannucchi AM, Migliaccio AR. Little steps toward the identification of the myelofibrotic locus. Blood 2003;101:5087-9.
  97. Migliaccio AR, Lorenzini R, Vannucchi AM, Spangrude GJ, Migliaccio G. Robust levels of long-term multilineage reconstitution in the absence of stem cell self-replication in W/Wv mice transplanted with purified stem cells. J Hematoter Stem Cell Res 2003;12:409-24.
  98. Migliaccio AR, Quarto R, Piacibello R: Cell Therapy. Filling the gap between basic science and clinical trials. Meeting Report. Stem Cells 2003;21:348-56. (Review).
  99. Centurione L, Di Baldassarre A, Zingariello M, Bosco D, Gatta V, Rana RA, Langella V, Di Virgilio A, Vannucchi AM, Migliaccio AR. Increased and pathological emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice. Blood 2004;104:3573-9.
  100. Migliaccio AR. Not children from a lesser God. Blood 2004;103:368-9.
  101. Di Giacomo V, Matteucci A, Stellacci E, Battistini A, Di Baldassarre A, Capitani S, Alfani E, Migliaccio AR, Cocco L, Migliaccio G. Expression of signal transduction proteins during the differentiation of primary human erythroblasts, J Cell Physiol 2005;202:831-8.
  102. Vannucchi AM, Bianchi L, Paoletti F, Pancrazzi A, Torre E, Nishikawa M, Zingariello M, Di Baldassarre A, Rana RA, Lorenzini R, Alfani E, Migliaccio G, Migliaccio AR. A patho-biological pathway linking thrombopoietin, GATA-1 and TGF-b1 in the development of myelofibrosis. Blood 2005;105:3493-501.
  103. Migliaccio G, Di Baldassarre A, Di Rico C, Di Noia A, Nakamoto B, Cao H, Skarpidi E, Migliaccio AR. Spontaneous switch from Ag- to b-globin promoter activity in a stable transfected dual reporter vector. Blood Cells Mol Dis 2005;34:174-180.
  104. Vannucchi AM, Pancrazzi A, Bianchi L, Guglielmelli P, Di Lollo S, Bogani C, Baroni G, Bosi A, Paoletti F, Migliaccio AR. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. Am J Pathol 2005;167:849-58
  105. Amabile G, Di Noia A, Alfani E, Vannucchi AM, Sanchez M, Migliaccio AR, Migliaccio G. Isolation of pure megakaryocytic clones (32D TPO) from the murine multipotent and IL-3-dependent 32D cell line. Blood Cells Mol Dis 2005;35:241-52.
  106. Martelli F, Ghinassi B, Panetta B, Alfani E, Gatta V, Pancrazzi A, Bogani C, Vannucchi AM, Paoletti F, Migliaccio G, Migliaccio AR. Variegation of the phenotype induced by the GATA-1low mutation in mice of different genetic background. Blood 2005;106:4102-13.
  107. Migliaccio AR, Philipsen S. Reflection on the EUrythron network meeting “Molecular Control of Erythropoiesis”, September 22-23, 2005, Instituto Superiore di Sanità, Rome, Italy. Stem Cells. (Editorial).
  108. Vannucchi AM, Migliaccio AR, Paoletti F, Chagraoui H, Wendling F. Pathogenesis of myelofibrosis with myeloid metaplasia: lessons from mouse models of the disease. Seminars in Oncology. 2005;32:365-72.
  109. Sanchez M, Weissman IL, Pallavicini M, Valeri M, Vannucchi AM, Migliaccio G, Migliaccio AR:Differential amplification of murine bipotent megakaryocytic/erythroid “progenitor” and “precursor” cells during the recovery from acute and chronic erythroid stress. Stem Cells 2006;24:337-48.
  110. Migliaccio AR, Vannucchi AM, Migliaccio G, Hoffman R. Molecular advances toward the understanding of the patho-biology of idiopathic myelofibrosis. Cur Immunol 2006; 2:169-186. (Review).
  111. Migliaccio AR, Philipsen S. The return of Romeo – Scientists' international mobility and the future of research in Europe.; EMBO Reports, 2006;7:1067-71. (Editorial).
  112. Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi AM, Migliaccio G, Orkin SH, Migliaccio AR. The hypomorphic Gata1low mutation alters the proliferation/ differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 2007;109:1460-71.
  113. Guglielmelli P, Zini R, Bogani C, Salati S, Pancrazzi A, Bianchi E, Mannelli F, Ferrari S, Le Bousse-Kerdilès MC, Bosi A, Barosi G, Migliaccio AR, Manfredini R, Vannucchi AM. Molecular profiling of CD34+ cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms Tumor 1. Stem Cells 2007;25:165-73.
  114. Ghinassi B, Verrucci M, Jelicic K, Di Noia A, Migliaccio G, Migliaccio AR. Interleukin-3 and erythropoietin cooperate in the regulation of the expression of lineage-specific transcription factors during erythroid differentiation, Exp Hematol, 2007;35:735-47.
  115. Di Baldassarre A, Di Rico MC, Di Noia A, Confini T, Icone A, Marchisio M, Miscia S, Alfani E, Migliaccio AR, Stamatoyannopoulos G, Migliaccio G. Protein Kinase C induces expression of a reporter gene under the control of the Agamma globin-promoter in cellular models of hemoglobin switching. J Cell Biochem 2007;101:411-24.
  116. Migliaccio AR, To code or not to code. Progress has been made toward the definition of “master-plan elements”, genes that encode spatiotemporal patterns of expression during development. Blood 2007;109:5077-8.
  117. Zetterberg E, Vannucchi AM, Migliaccio AR, Vainchenker W, Tulliez M, Dickie R, Hasselbalch H, Rogers R, Palmblad J. Pericyte coverage of abnormal blood vessels in myelofibrosis bone marrows. Haematologica 2007;92:597-604.
  118. Mai A, Jelicic K, Rotili D, Di Noia A, Alfani E, Valente S, Altucci A, Nebbioso A, Massa S, Galanello R, Brosch G, Migliaccio AR, Migliaccio G. Identification of new synthetic histone deacetylase (HDAC) inhibitors that alter the globin gene expression ratios in cellular models of Hb switch. Mol Pharmacol 2007;75:1111-23.
  119. Martelli F, Ghinassi B, Lorenzini R, Vannucchi AM, Rana RA, Nishikawa M, Partamian S, Migliaccio G, Migliaccio AR. Thrombopoietin inhibits murine mast cell differentiation. [http://www.ncbi.nlm.nih.gov/pubmed/18276801?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum] Stem Cells 2008;26:912-9.
  120. Migliaccio AR, Martelli F, Verrucci M, Migliaccio G, Vannucchi AM, Ni H, Xu M, Jiang Y, Nakamoto B, Papayannopoulou T, Hoffman R. Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease. Exp Hemat 2008;36:158-71.
  121. Migliaccio AR, Rotili D, Nebbioso A, Atweh G, Mai A. Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia. Int J Biochem Cell Biol. 2008;40(11):2341-7. Epub 2008 May 29.
  122. Stellacci E, Di Noia A, Di Baldassarre A, Migliaccio G, Battistini A, and Migliaccio AR. Interaction between the glucocorticoid and the erythropoietin receptors in human erythroid cells. Exp Hemat, 2009, 37:559-572.
  123. Ghinassi B, Zingariello M, Martelli F, Lorenzini R, Vannucchi AM, Rana RA, Nishikawa M, Migliaccio G, Mascarenhas J, Migliaccio AR. Increased differentiation of dermal mast cells in mice lacking the Mpl gene. Stem Cells Dev 2009;18:1081-92.
  124. Mutschler M, Magin AS, Buerge M, Will B, Pilz IH, Migliaccio AR, and Pahl HL. NF-E2 Overexpression Delays Erythroid Maturation and Increases Erythrocyte Production. Brit J Haemat 2009;146:203-17.
  125. Migliaccio G, Sanchez M, Leblanc A, Masiello F, Tirelli V, Migliaccio AR, Najfeld V, Whitsett C. Long term storage does not alter functionatlity of in vitro generated human erythroblasts: implications for ex vivo generated erythroid transfusion products. Transfusion. 2009; 49(12):2668-79.
  126. Rotili D, Simonetti G, Savarino A, Palamara AT, Migliaccio AR, Mai A. Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies. Curr Top Med Chem. 2009;9(3):272-91.
  127. Migliaccio AR, Whitsett C, Migliaccio G. Erythroid cells in vitro: from developmental biology to blood transfusion products. Curr Opin Hematol. 2009 Jul;16(4):259-68.
  128. Migliaccio AR, Martelli F, Verrucci M, Sanchez M, Valeri M, Migliaccio G, Vannucchi AM, Zingariello M, Di Baldassarre A, Ghinassi B, Rana RA, van Hensbergen Y, Fibbe WE. Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation. Blood. 2009 Sep 3;114(10):2107-20.
  129. Varricchio L, Mancini A, Migliaccio AR. Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis. Expert Rev Hematol. 2009 Jun 1;2(3):315-334.
  130. Varricchio L, Fabucci ME, Alfani E, Godbold J, Migliaccio AR. Compensated variability in the expression of globin-related genes in erythroblasts generated ex vivo from different donors. Transfusion. 2010 Mar;50(3):672-84.
  131. Ghinassi B, Martelli F, Verrucci M, D'Amore E, Migliaccio G, Vannucchi AM, Hoffman R, Migliaccio AR. Evidence for organ-specific stem cell microenvironments. J Cell Physiol. 2010 May;223(2):460-70.
  132. Migliaccio G, Migliaccio AR. Getting personal with B19 parvovirus. Blood. 2010 Feb 4;115(5):922-3.
  133. Migliaccio G, Sanchez M, Masiello F, Tirelli V, Varricchio L, Whitsett C, Migliaccio AR. Humanized culture medium for clinical expansion of human erythroblasts. Cell Transplant. 2010;19(4):453-69.
  134. Kozma GT, Martelli F, Verrucci M, Gutiérrez L, Migliaccio G, Sanchez M, Alfani E, Philipsen S, Migliaccio AR. Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells. Exp Hematol. 2010 Jun;38(6):489-503.e1.
  135. Zingariello M, Fabucci ME, Bosco D, Migliaccio AR, Martelli F, Rana RA, Zetterberg E. Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. Biotech Histochem. 2010 Apr 28;85(3):157-70.
  136. Verrucci M, Pancrazzi A, Aracil M, Martelli F, Guglielmelli P, Zingariello M, Ghinassi B, D'Amore E, Jimeno J, Vannucchi AM, Migliaccio AR. CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin. J Cell Physiol. 2010 Nov;225(2):490-9.
  137. Perrotta S, Cucciolla V, Ferraro M, Ronzoni L, Tramontano A, Rossi F, Scudieri AC, Borriello A, Roberti D, Nobili B, Cappellini MD, Oliva A, Amendola G, Migliaccio AR, Mancuso P, Martin-Padura I, Bertolini F, Yoon D, Prchal JT, Della Ragione F. EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 cell differentiation and increases circulating endothelial precursors. PLoS One. 2010 Aug 5;5(8):e12015.
  138. Migliaccio AR. Erythroblast enucleation. Haematologica. 2010 Dec;95(12):1985-8.
  139. Varricchio L, Masselli E, Alfani E, Battistini A, Migliaccio G, Vannucchi AM, Zhang W, Rondelli D, Godbold J, Ghinassi B, Whitsett C, Hoffman R, Migliaccio AR. The dominant negative {beta} isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients. Blood. 2011 Jul 14;118(2):425-36.
  140. Eliades A, Papadantonakis N, Bhupatiraju A, Burridge KA, Johnston-Cox HA, Migliaccio AR, Crispino JD, Lucero HA, Trackman PC, Ravid K. Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase. J Biol Chem. 2011; 286(31):27630-8.
  141. Varricchio L, Godbold J, Scott SA, Whitsett C, Da Costa L, Pospisilova D, Garelli E, Quarello P, Ramenghi U, Migliaccio AR. Increased frequency of the glucocorticoid receptor A3669G (rs6198) polymorphism in patients with Diamond-Blackfan anemia. Blood. 2011; 118(2):473-4.
  142. Tirelli V, Ghinassi B, Migliaccio AR, Whitsett C, Masiello F, Sanchez M, Migliaccio G. Phenotypic Definition of the Progenitor Cells with Erythroid Differentiation Potential Present in Human Adult Blood. Stem Cells Int. 2011; 2011:602483.
  143. Migliaccio AR, Palis J. Blood in a dish: in vitro synthesis of red blood cells, Drug Discovery Today: Disease Mechanisms 2011; 8 (1–2), e3-e8.
  144. Ghinassi B, Ferro L, Masiello F, Tirelli V, Sanchez M, Migliaccio G, Whitsett C, Kachala S, Riviere I, Sadelain M, Migliaccio AR. Recovery and Biodistribution of Ex vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rγnull mice. Stem Cells Int. 2011; 2011:673752.
  145. Migliaccio G [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Migliaccio%20G%22%5BAuthor%5D], Masiello F [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Masiello%20F%22%5BAuthor%5D], Tirelli V [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Tirelli%20V%22%5BAuthor%5D], Sanchez M [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sanchez%20M%22%5BAuthor%5D], Varricchio L, Whitsett C [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Whitsett%20C%22%5BAuthor%5D], [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Migliaccio%20AR%22%5BAuthor%5D] . Under HEMA conditions, self-replication of human erythroblasts is limited by autophagic death. Blood Cells Mol Dis. [http://www.ncbi.nlm.nih.gov/pubmed/21775174##] 2011; 47(3):182-97.
  146. [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Migliaccio%20AR%22%5BAuthor%5D], Bieker JJ [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bieker%20JJ%22%5BAuthor%5D] . GATA2 finds its macrophage niche. Blood [http://www.ncbi.nlm.nih.gov/pubmed/21903902##] 2011 Sep 8;118(10): 2647-9.
  147. Migliaccio AR, Masselli E, Varrichio L, Whisett L.Ex-Vivo Expansion of Red Blood Cells: How Real for Transfusion in Humans? Blood Review. 2012; 26(2):81-95.
  148. Varricchio L, Tirelli V, Masselli E, Ghinassi B, Besmer P, Migliaccio AR. The expression of the glucocorticoid receptor in human erythroblasts is uniquely regulated by KIT ligand: implications for stress erythropoiesis. [http://www.ncbi.nlm.nih.gov/pubmed/22533504] Stem Cells Dev. 2012 10;21(15):2852-65.
  149. Migliaccio AR, Whitsett C, Papayannopoulou T, Sadelain M. The Potential of Stem Cells as an In Vitro Source of Red Blood Cells for Transfusion. Cell Stem Cell. 2012; 10(2); 115-9 (republished online among the best reviews on the subject of Cell Therapy published by Cell Stem Cells in 2013).
  150. Migliaccio AR, Masselli E, Varricchio L, Whitsett C. Ex-vivo Expansion of Red Blood Cells: How Real for Transfusion in Humans? Blood Reviews 2012; 26(2): 81-95. PMID: 22177597
  151. Zeuner A, Martelli F, Vaglio S, Federici G, Whitsett C, Migliaccio AR. Stem Cell-Derived Erythrocytes as Upcoming Players in Blood Transfusion. Stem Cells. 2012; 8; 1587-96; PMID: 22644674
  152. Poletto V [http://www.ncbi.nlm.nih.gov/pubmed?term=Poletto%20V%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Rosti V [http://www.ncbi.nlm.nih.gov/pubmed?term=Rosti%20V%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Villani L [http://www.ncbi.nlm.nih.gov/pubmed?term=Villani%20L%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Catarsi P [http://www.ncbi.nlm.nih.gov/pubmed?term=Catarsi%20P%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Carolei A [http://www.ncbi.nlm.nih.gov/pubmed?term=Carolei%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Campanelli R [http://www.ncbi.nlm.nih.gov/pubmed?term=Campanelli%20R%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Massa M [http://www.ncbi.nlm.nih.gov/pubmed?term=Massa%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Martinetti M [http://www.ncbi.nlm.nih.gov/pubmed?term=Martinetti%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Viarengo G [http://www.ncbi.nlm.nih.gov/pubmed?term=Viarengo%20G%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Malovini A [http://www.ncbi.nlm.nih.gov/pubmed?term=Malovini%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], [http://www.ncbi.nlm.nih.gov/pubmed?term=Migliaccio%20AR%5BAuthor%5D&cauthor=true&cauthor_uid=22879541], Barosi G [http://www.ncbi.nlm.nih.gov/pubmed?term=Barosi%20G%5BAuthor%5D&cauthor=true&cauthor_uid=22879541] . A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation. Blood. [http://www.ncbi.nlm.nih.gov/pubmed?term=poletto%20V%20A3669G%20polymorphism] 2012; 120(15):3112-7. PMID: 22879541
  153. Revelli N, Paccapello C., Manera M.C, Rebulla P., Migliaccio AR., Marconi M, The Lombardy rare donor Program, Blood Transfussion; Blood Transfus. [http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Lombardy+rare+donor+Program%2C+Blood+Transfussion] 2013 Feb 21:1-7. doi: 10.2450/2013.0182-12. PMID: 23522888[Epub ahead of print]
  154. Zingariello M, Martelli F, Ciaffoni F, Masiello F, Ghinassi B, D’Amore E, Massa M, Barosi G, Sancillo L, Li X, Godberg J, Rana RA, Migliaccio AR; Characterization of TGF-β1 Signaling abnormalities in the Gata1lowmouse model of myelofibrosis; Blood. 2013 Apr 25;121(17):3345-63. doi: 10.1182/blood-2012-06-439661. Epub 2013 Mar 5.
  155. Hricik T, Federici G, Zeuner A, Alimena G, Tafuri A, Tirelli V, Varricchio L, Masiello F, Ciaffoni F, Vaglio S, Petricoin EF, Girelli G, Levine RL, Migliaccio AR.Transcriptomic and phospho-proteomic analyses of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera.Am J Hematol. 2013 Sep; 88(9):723–9. doi: 10.1002/ajh.23487.
  156. Migliaccio, AR. A niche for every cell, for every function. Haematologica 2013 Nov 98(11):1660-3. doi: 10.332/haematol.2013094466.
  157. Zetterberg E, Verrucci M, Martelli F, Zingariello M, Sancillo L, D'Amore E, Rana RA, Migliaccio AR. Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosis. Platelets. 2014;25(7):539-47. doi: 10.3109/09537104.2013.840720.
  158. Masiello F, Tirelli V, Sanchez M, van den Akker E, Gabriella G, Marconi M, Villa MA, Rebulla P, Hashmi G, Whitsett C, Migliaccio AR. Mononuclear cells from a rare blood donor, after freezing under good manufacturing practice conditions, generate red blood cells that recapitulate the rare blood phenotype. [http://www.ncbi.nlm.nih.gov/pubmed/24004289] Transfusion. 2014 Apr;54(4):1059-70. doi: 10.1111/trf.12391. Epub 2013 Sep 4.
  159. Varricchio L, Dell'Aversana C, Nebbioso A, Migliaccio G, Altucci L, Mai A, Grazzini G, Bieker JJ, Migliaccio AR. Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells. [http://www.ncbi.nlm.nih.gov/pubmed/24594363] Int J Biochem Cell Biol. 2014 May;50:112-22. doi: 10.1016/j.biocel.2014.02.019. Epub 2014 Mar 1.
  160. Paciaroni, K; Lucarelli, G; Martelli, F; Migliaccio, AR; von Lindern, M; Borg, J; Gillemans, N; van Dijk, TB; Philipsen, S; "Transfusion-independent β0-thalassemia after bone marrow transplantation failure: proposed involvement of high parental HbF and an epigenetic mechanism. Am J Blood Res. 2014 Sep 5;4(1):27-32. eCollection 2014
  161. Migliaccio, AR; Stem cell-derived erythrocytes as upcoming players in blood transfusion.ISBT Science Series (2013) 8, 165-171; VOXS, Sanguinis 2013,
  162. Falchi M, Varricchio L, Martelli F, Masiello F, Federici G, Zingariello M, Girelli G, Whitsett C, Petricoin EF, Moestrup SK, Zeuner A, Migliaccio AR. Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion. [http://www.ncbi.nlm.nih.gov/pubmed/25533803] Haematologica 2015 Feb;100(2):178-87. doi:10.3324/haematol.2014.114405. Epub 2014 Dec 22
  163. Varricchio, L; Migliaccio, AR; The Role of Glucocorticoid receptor (GR) polymorphisms in human erythropoiesis; Am J Blood Res 2014 Dec 15;4(2):53-72. eCollection 2014.
  164. Ciaffoni F, Cassella E, Varricchio L, Massa M, Barosi G, Migliaccio AR. Activation of non-canonical TGF-β1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis.Blood Cells Mol Dis. 2015 Mar; 54(3):234-41. doi: 10.1016/j.bcmd.2014.12.005. Epub 2015 Jan 15.
  165. Heideveld E,Masiello F, Marra M, Esteghamat, F, Yagci N, Lindern VM, Migliaccio AR, Van Den Akker, E;CD14+ cells from peripheral blood positively regulate CD34+ survival resulting in increased erythroid yield. Haematologia; 2015 Nov;100(11):1396-406. doi: 10.3324/haematol.2015.125492. Epub 2015 Aug 20
  166. Spangrude GJ, Lewandowski D, Martelli F, Marra M, Zingariello M, Sancillo D, Rana RA, Migliaccio AR.P-selectin sustains extramedullary hematopoiesis in the Gata1low model of myelofibrosis.Stem Cells; 2016 Jan;34(1):67-82. doi: 10.1002/stem.2229. Epub 2015 Oct 23.
  167. Funnell AP, Prontera P, Ottaviani V, Piccione M, Giambona A, Maggio A, Ciaffoni F, Stehling-Sun S, Marra M, Masiello F, Varricchio L, Stamatoyannopoulos JA, Migliaccio AR, Papayannopoulou T. 2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment. Blood 2015 Jul 2;126(1):89-93. doi: 10.1182/blood-2015-04-638528. Epub 2015 May 27.
  168. Migliaccio AR, The “gift to be simple” or “How to become a legend”; A perspective on Donald’s Legacy from a former postdoctoral fellows of the ‘70s. Stem Cells, 2015; vol. 33: pg.3408-3411
  169. Von Lindern M, van den Akker E, Anstee D, Baruch D, Flygare J, Migliaccio AR, Miharada K, El Nemer W, Toye AM, Douay L, Towards large scale production of blood cells for transfusion purposes identifying the requirements for cost effective industrial production. Chapter 7.7 of the European Hematology Association (EHA) Roadmap on Hematology Research in Europe: A consensus document Version 9.6.2015; Engert A, Balduini CL, Brand A, Coiffier B, Cordonnier C, de Haas F, Döhner H, Duyvené de Wit T, Eichinger S, Fibbe W, Green T, Lolascon A, Jaffredo T,Rodeghiero F, Salles G, Schuringa JJ. Haematologica 2016 Feb;101(2):115-208. doi: 10.3324/haematol.2015.136739. Epub 2016 Jan 27.
  170. Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NL, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S; State of the Science in Transfusion Medicine Working Groups. 2015 Proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium. Transfusion. 2015 Sep;55(9):2282-90. doi: 10.1111/trf.13250. Epub 2015 Aug 10. PMID: 26260861
  171. Migliaccio AR. Forever young: 44 years old and still going strong. PMID: 27329004 DOI:Exp Hematol. 2016 Jun 18. pii: S0301-472X(16)30191-6. doi: 10.1016/j.exphem.2016.06.004.
  172. Migliaccio AR. To condition or not to condition-This is the question: The evolution of nonmyeloablative conditions for transplantation; Exp Hematol. 2016 May 6. pii: S0301-472X(16)30120-5. doi: 10.1016/j.exphem.2016.04.016. PMID: 27157594
  173. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG,Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M,Migliaccio AR + authors: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.
  174. Murphy A, Murphy MJ, Begley CG, Stanley ER, Migliaccio AR, Kaushansky K, Ng AP, Alexander WS, Hilton DJ, Nicola NA.; Tribute to Donald Metcalf.A collection of tributes and remembrances from esteemed colleagues, mentees, and friends on the life and work of "the father of hematopoietic cytokines". Stem Cells. 2015 Dec;33(12):3397-421. doi: 10.1002/stem.2237. PMID:26976235
  175. Zingariello M, Ruggeri A, Martelli F, Marra M, Sancillo L, Ceglia I, Rana RA, Migliaccio AR; A novel interaction between megakaryocytes and activated fibrocytes increases TGF-β bioavailability in the Gata1(low) mouse model of myelofibrosis. Am J Blood Res. 2015 Dec 25;5(2):34-61. eCollection 2015. PMID: 27069753PMCID:PMC4769347(Not included in 2015)
  176. Gilles L, Arslan D, Arya P, Marinaccio C, McNulty M, Wen QJ, Yang Q, Zhao JC, Konstantinoff K, Lasho T, Pardanani A, Stein B, Plo I, Sundaravel S, Wickrema A, Migliaccio AR, Gurbuxani S, Vainchenker W, Platanias L, Tefferi A, Crispino J ; Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. J Clin Invest. 2017;127(4):1316-1320. doi: 10.1172/JCI82905. Epub 2017 Feb 27
  177. Ceglia I, Dueck AC, Masiello F, Martelli F, He W, Federici G, Petricoin EFIII, Zeuner A, Iancu-Rubin, C, Weinberg R, Hoffman R, Mascarenhas J, Migliaccio AR, Pre-clinical rationale for TGF-β inhibition as a therapeutic target for the treatment of myelofibrosis.Exp Haematology; 2016; 44:1138-1155. pii: S0301-472X(16)30569-0. doi: 10.1016/j.exphem.2016.08.007
  178. Zingariello MSancillo L, Martelli F, Ciaffoni F, Marra M, Varricchio L, Rana R A, Zhao C, J Crispino D, Migliaccio AR; The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature; Blood Cancer Journal 2017;7,e572; doi:10.1038/bcj.2017.51
  179. Falchi M, Varricchio L, Martelli F, Marra M, Picconi O, Tafuri A, Girelli G, Uversky VN, Migliaccio AR. The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera. Exp Hematol. 2017 Jun;50:53-76. doi: 10.1016/j.exphem.2017.02.001
  180. Migliaccio AR; Miss Piggy on the catwalk again; Blood. 2017 Nov 16;130(20):2153-2154. doi: 10.1182/blood-2017-10-809640.PMID: 29146816
  181. Varricchio L, Falchi M, Dall'Ora M, De Benedittis C, Ruggeri A, Uversky VN, Migliaccio AR; Calreticulin: Challenges Posed by the Intrinsically Disordered Nature of Calreticulin to the Study of Its Function.; Front Cell Dev Biol. 2017 Nov 23;5:96. doi: 10.3389/fcell.2017.00096. eCollection 2017
  182. Migliaccio AR, [https://www.sciencedirect.com/science/article/pii/S0301472X17309104?via%3Dihub#!] Hoffman [https://www.sciencedirect.com/science/article/pii/S0301472X17309104?via%3Dihub#!] R. Remembering Ihor Lemischka—The scientist's scientist. Exp Hematol 2018 Feb; 58:1-4. https://doi.org/10.1016/j.exphem.2017.12.011
  183. Migliaccio AR; A vicious interplay between genetic and environmental insults in the etiology of blood cancers; Exp Hematol. 2018 Mar;59:9-13. doi:10.1016/j.exphem.2017.12.004
  184. Migliaccio AR, Vladimir N. Uversky; Dissecting physical structure of calreticulin, an intrinsically disordered Ca2+-buffering chaperone from endoplasmic reticulum; J Biomol Struct Dyn 2018 May;36(6):1617-1636. doi: 10.1080/07391102.2017.1330224.
  185. Ling T, Crispino JD, Zingariello M, Martelli F, Migliaccio AR; GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy. Expert Rev Hematol. 2018 Mar;11(3):169-184. doi: 10.1080/17474086.2018.1436965. Epub 2018 Feb 19. PMID:29400094
  186. Migliaccio AR, Varricchio L; Concise Review: Advanced Cell Culture Models for Diamond Blackfan Anemia and Other Erythroid Disorders. Stem Cells. 2018 Feb;36(2):172-179. doi:10.1002/stem.2735
  187. Malara A, Abbonante V, Migliaccio AR, Balduini A. Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver. Mediterr J Hematol Infect Dis. 2018 Nov 01;10(1):e2018068. doi: 10.4084/MJHID.2018.068. eCollection 2018
  188. Iancu-Rubin C, Hoffman R, Migliaccio AR. Whirling Platelets Away for Transfusion. Cell. 2018 Jul 26;174(3):503-504. doi: 10.1016/j.cell.2018.07.018.
  189. Zingariello M, Bardelli C, Sancillo L, Ciaffoni F, Genova ML, Girelli G and Migliaccio AR. Dexamethasone predisposes human erythroblasts toward impaired lipid metabolism and renders their ex-vivo expansion highly dependent on plasma lipoproteins. Front. Physiol. 04 April 2019. https://doi.org/10.3389/fphys.2019.00281.
  190. Eran Z, Zingariello M, Migliaccio AR. Novel strategies forthe treatment of myelofibrosis, the most severe of the Philadelphia-negative myeloproliferative neoplasms, driven by recent advances in the understanding of its pathogenesis. F1000Res. 2019 March 11 (submitted).

    Invited Contributions

  191. Peschle C, Rossi G.B, Lettieri F, Migliaccio AR, Migliaccio G, Di Rosa M, Condorelli M. Modulation of in vitro hemopoiesis by PGE and cAMP. Species-dependent influences on erythroid precursors. In: In Vivo and In Vitro Erythropoiesis: The Friend System, Rossi GB, (Ed.). Amsterdam. Elsevier 1980.
  192. Ottolenghi S, Peschle C, Comi, P, Giglioni B, Pozzoli ML, Cappellini N, Migliaccio AR, Lettieri F, Migliaccio G, Barba P, Covelli A, Gianni AM. Hemoglobin synthesis in single erythroid colonies from cord and adult blood. In:In Vivo and In Vitro Erythropoiesis:The Friend System, Rossi GB, (Ed.). Amsterdam:Elsevier, 1980.
  193. Peschle C, Migliaccio AR, Migliaccio G, Lettieri, F, Quattrin, S, Quattrin, M, Condorelli, M, Gianni, A.M, Sciortino, G, Giglioni, B, Ottolenghi S, Comi, P. Erythroid precursors in human fetal liver and adult marrow: Clonal analysis and globin chains synthesis in single colonies. In:In Vivo and In Vitro Erythropoiesis:The Friend System, Rossi, G.B. (Ed.). Amsterdam:Elsevier, 1980.
  194. Peschle C, Migliaccio AR, Migliaccio G, Lettieri F, Sasso GF, Comi P, Giglioni B, Pozzoli ML, Ottolenghi S, Gianni AM. Regulation of Hb synthesis in ontogenesis and erythropoietic differentiation: Studies in normal humans. In:First International Conference on Fetal Liver Transplantation, Fliedner TM, Gale RP, Lucarelli G. (Eds.). Amsterdam. Elsevier 1980.
  195. Peschle C, Migliaccio AR, Migliaccio G, Lettieri F, Maguire YP, Condorelli M, Gianni AM, Ottolenghi S, Giglioni G, Pozzoli ML, Comi P. Regulation of Hb synthesis in ontogenesis and erythropoietic differentiation. In vitro studies on fetal liver, cord blood, adult blood or marrow, and in HPFH patients. In Stamatoyannopoulos G, Nienhuis A, (Eds.). Hemoglobin in Development and Differentiation. New York. Alan R. Liss, Inc, 1981.
  196. Peschle C, Migliaccio G, Migliaccio AR, Ciccariello R, Gianni AM, Ottolenghi S, Giglioni B, Comi P. The Hb switches in ontogenesis and erythropoietic differentiation: a unifying model. In: Advances in Red Blood Cell Biology, Weatherall DJ, and Fiorelli G. (Eds.). New York. Raven Press 1982.
  197. Ottolenghi S, Comi P, Giglioni B, Gianni AM, Migliaccio AR, Migliaccio G, Lettieri F, Ciccariello R, Peschle C. Cellular mechanisms for regulation of Hb synthesis. In: Expression of Differentiated Functions in Cancer Cells, Revoltella G, Pontieri G, Rovera G, Basilico C, Gallo R, Subak-Sharpe J. (Eds.). New York:Raven Press, 1982.
  198. Peschle C, Rossi, G.B, Covelli, A, Migliaccio G, Migliaccio AR. Mastroberardino G. The early stage of Friend virus erythroleukemias:mechanisms underlying BPA "independent" in vitro growth of BFU-E. In: Modern Trends in Human Leukemia, Neth R, Gallo R. (Eds.). New York: Springer-Verlag 1982.
  199. Peschle C, Migliaccio AR, Migliaccio G, Mastroberadino G, Gianni AM, Comi P, Ottolenghi S, Giglioni B. In vitro regulation of Hb synthesis: studies in normal subjects and thalassemic patients. In:Thalassemia: Recent Advances in Detection and Treatment, Cao A, Carcassi U, Rowley PT. (Eds.). New York: Alan R. Liss, 1982;18
  200. Peschle C, Migliaccio AR, Migliaccio G, Russo, G, Mastroberardino G, Ottolenghi S, Giglioni B, Comi P, Gianni AM, Presta M, Mavilio F, Giampaolo A, Caré A, Marinucci M. Cellular and molecular mechanisms of the human embryonic fetal Hb switch. In:Globin Gene Expression and Hematopoietic Differentiation. Stamatoyannopoulos G, Nienhuis A. (Eds,). New York. Alan R. Liss, 1983.
  201. Peschle C, Migliaccio AR, Migliaccio G, Russo G, Mastroberardino G, Presta M, Gianni AM, Comi P, Giglioni B, Ottolenghi S. Mechanism underlying the embryonic fetal Hb switch in human embryos. In:Frontiers in Experimental Hematology, Torelli U. et al, (Eds.). Serono Symposia, 1983 pp. 48-51.
  202. Migliaccio AR, Migliaccio G, Gabbianelli M, Guerriero R, Del Sordo R, Rossi GB, Mastroberardino G, Peschle C, G. Cudkowicz. Differential release of hemopoietins (GM-CSF, BPA) by selected murine T-lymphocyte cell lines. In: Frontiers in Experimental Hematology, Torelli U, et al, (Eds.). Serono Symposia, 1983 pp. 115-8.
  203. Peschle C, Rossi G.B, Migliaccio G, Migliaccio AR, Mastroberardino G. Friend virus erythroleukemia. A temptative model for the erythropoietic preleukemic stage. In:Frontiers in Experimental Hematology, Torelli, U. et al, (Eds.). Serono Symposia, 1983 pp. 157-60.
  204. Mastroberardino G, Migliaccio G, Migliaccio AR, Covelli A, Peschle C. Modulation of the kinetics of erythroid progenitors in hemopoietic microenvironment:possible role of PGE. In:Frontiers in Experimental Hematology, Torelli U. et al, (Eds.). Serono Symposia, 1983 pp. 161-4.
  205. Peschle C, Migliaccio G, Lazzaro D, Petti S, Mancini G, Car A, Russo G, Mastroberardino G, Migliaccio AR, Testa U. Hemopoietic development in human embryos: transition from yolk sac to liver erythropoiesis and Hb switching. Blood Cells 1984;10:427-41.
  206. Migliaccio G, Avitabile L, Migliaccio AR, Petti S, Guerriero P, Amadori S, Mandelli F, Peschle C. A new human erythroleukemic line:initial characterization and hemin-induced erythroid differentiation. In: Genetic and Phenotypic Markers of Tumors, Aaronson SA, Frati L, Verna R. (Eds.). New York. Plenum Press, 1984.
  207. Peschle C, Migliaccio AR, Migliaccio G, Mavilio F, Rocca E, Petrini M, Mastroberardino G, Comi P, Giglioni B, Ottolenghi S. A model for hemoglobin F synthesis in adult life: evidence for regulation at the level of erythroblast. Ann NY Acad Sci 1985;445:225-34.
  208. Petti S, Testa U, Migliaccio AR, Mavilio F, Marinucci M, Lazzaro D, Russo G, Mastroberardino G, Peschle C. Embryonic hemopoiesis in human liver: morphological aspects at sequential stages of ontogenic development. In: Fetal Liver Transplantation, Gale RP, Tourain JL, Lucarelli G. (Eds.). New York. Alan R. Liss, 1985 pp. 57-72.
  209. Peschle C, Mavilio, F, Migliaccio G, Migliaccio AR, Russo G, Mastroberardino G, Marinucci M. Erythropoietic development and hemoglobin switching in human embryos:cellular and molecular aspects. In: Experimental Approaches for the Study of Hemoglobin Switching, Stamatoyannopoulos G, Nienhuis A. (Eds.). New York: Alan R. Liss, 1985 pp. 383-96.
  210. Migliaccio G, Migliaccio AR, Russo G, Peschle C. Embryonic-fetal hemopoiesis in humans. Kinetics of hemopoietic progenitors in yolk sac, liver and blood and initial characterization of their in vitro growth factor requirements. Cell Biol Int Rep 1986;10:479.
  211. Migliaccio AR, Migliaccio G, Ferrero D, Russo G, Peschle C. Colony-inhibiting factor (CIL) from T-cell lines suppresses proliferation of adult but not embryonic-fetal hemopoietic progenitors. In:Biological Regulation of Cell Proliferation, Baserga R, Foa P, Metcalf D, Polli EE. (Eds.). New York. Raven Press, 1986.
  212. Migliaccio G, Migliaccio AR. Early hemopoietic differentiation:the action of multi-CSF is complemented by lineage specific growth factors. Ann NY Acad Sci 1987;511:39-49.
  213. Peschle C, Migliaccio G, Migliaccio AR, Marinucci M, Mastroberardino G. Hemoglobin switching in humans. In: Thalassemia Today Sirchia G, Zanella A, (Eds.). Ospedale Maggiore Policlinico di Milano, Milano, 1987 pp. 3-17.
  214. Migliaccio G, Migliaccio AR, Broudy V, Kreider B, Rovera G, Adamson JW. Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32 D. Hemoglobin Switching. Part B: Cellular and Molecular Mechanisms. Stamatoyannopoulos G, Nienhuis AW. (Eds.). New York. Alan R. Liss. Progress in Clinical and Biological Research 1989;316B:183-196.
  215. Ottolenghi S, Ronchi A, Crotta S, Nicolis S, Santoro C, Ruzzi L, Shimada Y, Migliaccio AR, Migliaccio G. Studies of erythroid nuclear factors. In: The Regulation of Hemoglobin Switching. Stamatoyannopoulos G, Nienhuis AW. (Eds.). Baltimore, The Johns Hopkins University Press 1991.
  216. Migliaccio AR, Migliaccio G, Ruzzi L, Satiropoulos D, Crotta S, Nicolis S, Ottolenghi S, Adamson JW. Erythropoietin-responsiveness during erythroid differentiation is acquired through post-transcriptional regulation of the expression of the erythropoietin receptor gene. In: The Regulation of Hemoglobin Switching. Stamatoyannopoulos G, Nienhuis AW. (Eds.). Baltimore, The Johns Hopkins University Press 1991.
  217. Migliaccio AR, Migliaccio G, D’Andrea, A, Baiocchi M, Ruzzi, L, Crotta, S, Nicolis S, Ottolenghi S, Adamson JW. Molecular mechanisms underlying the erythroid specificity of the cellular response to erythropoietin (Epo). In:Molecular Biology of Haematopoiesis, Vol. 2. Proceedings of the International Conference on Molecular Biology of Hematopoiesis. N. Abraham , G. Konwalinka, P. Marks, L. Sachs, M. Tavassoli (Eds.). Intercept. Andover, Hants, UK, pp. 93-107, 1992.
  218. Migliaccio G, Migliaccio AR, Druzin ML, Giardina PJV, Zsebo KM, Adamson JW. The effect of recombinant human stem cell factor (SCF) on cord blood progenitor cell growth and the generation of colony-forming cells (CFC) from pre-CFC in liquid culture. In: Molecular Biology of Haematopoiesis, Vol. 2. Proceedings of the International Conference on Molecular Biology of Hematopoiesis. N. Abraham, G. Konwalinka, P. Marks, L. Sachs, M. Tavassoli (Eds.). Intercept. Andover, Hants, UK. 1992 pp. 49-63.
  219. Durand B, Samal B, Migliaccio AR, Migliaccio G, Adamson JW. Macrophage inhibitory protein 1 (MIP-1a) and leukemia inhibitory factor (LIF) increase the number of colony-forming cells (CFC) in long-term cultures of human CD34+ cord blood cells. In: The negative regulation of Hematopoiesis. Guigon M. (ed.). Colloque INSERM/John Libbey Eurotext Ltd. 1993 pg. 155.
  220. Galli M.C, Giardina PJV, Migliaccio AR, Migliaccio G. The biology of stem cell factor, a new haematopoietic growth factor involved in stem cell regulation. Int J Clin Lab Res 1993;23:70-7. PMID:7686057
  221. Migliaccio AR, Baiocchi M, Durand B, Eddleman K, Migliaccio G, Adamson JW. Stem cell factor and the amplification of progenitor cells from CD34+ cord blood cells. Blood Cells 1994;20:129-39.
  222. Migliaccio AR, Migliaccio G, Adamson JW. Expansion of human neonatal stem and progenitor cells in vitro under serum deprived conditions. Blood Cells 1994;20:424-9.
  223. Durand B, Migliaccio AR, Adamson JW, Migliaccio G. Long-term culture of human mast cells from neonatal CD34+ cells stimulated with stem cell factor (SCF) and interleukin-3 (IL-3). In:Molecular Biology of Hematopoiesis. Abraham N, Shadduck RK, Levine AS, Takaku F. (Eds.). Andover, Intercept, 1994;3:191-200.
  224. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S. GATA-1 independent regulation of the expression of the erythropoietin receptor (Epo-R) in human Epo-responsive cell line. In: Molecular Biology of Hematopoiesis. Abraham N, Shadduck RK, Levine AS, Takaku F. (Eds.). Andover, Intercept, 1994;3:487-502.
  225. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S, Adamson JW. GATA-1 independent regulation of the expression of the erythropoietin receptor (Epo-R) gene in a human Epo-dependent cell line, UT-7 Epo. Ann NY Acad Sci 1994;718:359-61.
  226. Migliaccio AR, Migliaccio G, Ashihara E, Moroni E, Giglioni B, Ottolenghi S. Erythroid-specific activation of the distal (Testis) promoter of GATA-1 during differentiation of purified normal murine hematopoietic stem cells. Acta Haematologica 1996;95:229-35. Selected by the Scientific Committee to be published among the most significant reports of the meeting in “Molecular Biology of Hematopoiesis”, (N. Abraham et al. ed.) 1996;5:377-85.
  227. Migliaccio AR. Circulating Hematopoietic Stem Cells. Proceedings of Organization for Economic Cooperation and Development Workshop on Gene Delivery System, Ottawa, Canada, June 27-30, 1995. In:OECD Documents; Gene Delivery System. OECD Publications, Paris, 1996 pp. 195-205.
  228. Vannucchi AM, Linari S, Migliaccio AR. Expression of distal Gata1 transcripts in erythroid cells. In: Proceedings of the VIII International Conference on Molecular Biology of Hematopoiesis, Abraham n, Carella A. (editors). 1999;6:249-255.
  229. Sanchez M, Alfani E, Visconti G, Passarelli A.M, Migliaccio AR, Migliaccio G. Thymus-independent T cell differentiation in vitro. In: Proceedings of the VIII International Conference on Molecular Biology of Hematopoiesis, Abraham N, Carella A, (Eds.). 1999;6:51-7.
  230. Vannucchi AM, Paoletti F, Migliaccio G, Migliaccio AR, Clinical aspects of myelofibrosis and GATA-1 mutations. Atti del XVII Congresso della International Society of Hematology, Editor W Linkesch, Monduzzi Editore, ISBN 88-323-3148-9", 2003.
  231. Vannucchi AM, Bianchi L, Paoletti F, Viviana di Giacomo, Migliaccio G, Migliaccio AR. Impaired GATA-1 expression and myelofibrosis in animal models, Pathologie Biologie 2004;52:275-9.
  232. Migliaccio AR, Alfani E, Di Giacomo V, Cieri M, Migliaccio G: Ex vivo amplifications of T cells from human cord blood. Clinique Patologique 2005;53:151-8.
  233. Migliaccio AR, Rana RA, Vannucchi AM, Manzoli FA:Role of GATA-1 in normal and neoplastic hemopoiesis. Ann N Y Acad Sci 2005;1044:142-58.
  234. Migliaccio AR, Rana RA, AM Vannucchi FA Manzoli. Role of Thrombopoietin in mast cell differentiation. Ann N Y Acad Sci 2007;1106:152-74.
  235. Martelli F, Verrucci M, Migliaccio G, Zingariello M, Rana RA, Vannucchi AM,Migliaccio AR.Removal of the spleen in mice alters the cytokine expression profile of the marrow microenvironment and increase bone formation. Ann New York Acad. Sci. 2009; 1176:77-86.
  236. Varricchio, L; Migliaccio AR; Calreticulin in Myeloproliferative Neoplasms: The Other Side of the Alice Mirror, EMJ Hema. 2014: 1:114-122
  237. Migliaccio AR, Remembering Luisa Leone(1967 – 2014) Journal of the European Association for Health Information and Libraries 2014, Vol. 10(4) Contributed Commentary in remembering Dr. Leone.
  238. Migliaccio AR, Email interview. Respond to the European Haematology Journal, Online in July 2015

    Sponsored F1000 commentaries by junior laboratory members

    Lilian Varricchio:

  239. Comment on: [http://f1000.com/2508957] By Naka K, Hoshii T, Muraguchi T, Tadokoro Y, ..., Kondo Y, Nakao S, Motoyama N, Hirao A. Nature. 2010 Feb 4; 463(7281):676-80.Published on March 31st, 2010
  240. Comment on: [http://f1000.com/9433958] By Dutt S, Narla A, Lin K, Mullally A, ..., Khanna-Gupta A, Berliner N, Kutok JL, Ebert BL. Blood. 2011 Mar 3; 117(9):2567-76. Published on April 7th, 2011
  241. Comment on: Critical requirement for Stat5 in a mouse model of polycythemia area. By Yan D., Hutchinson RE., Mohi G., Blood 2012, 119: 3539-3549. Published on August 23rd, 2012
  242. Comment on: Genetic interaction between Kit and Science. By Lacombe J, Krosi G,Trembly M, Gerby B, Martin R, Aplan PD, Leieux S, Hoang T.Blood 2013 Aug 15; 122(7):1150-61 doi: 10.1182/blood-2011-01-331819;PMID: 23836559. Published on September 17th, 2013
  243. Comment on: Fev regulates hematopoietic stem cell development via ERK signaling1.By Wang L, Liu T, Xu L, Gao Y, Patient R, Zhang B, Hong D, Liu F. Blood 2013 Jul 18; 122(3):367-75. doi: 10.1182/blood-2012-10-462655; PMID: 23591790 Published on September 17th, 2013
  244. Comments on: Somatic mutations of calreticulin in myeloproliferative neoplasms.By Klampfl T, Gisslinger H, Harutyunyan AS, et al. N Engl J Med. 2013 Dec 19; 369(25):2379-90; 07 Mar 2014. Published onMarch 7th, 2014
  245. Comments on: MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. By Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. Blood. 2015 Nov 5; 126(19):2202-12. PMID: 26324703 Published on March 22nd, 2016

    Elena Masselli

  246. Comment on: Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. By England SJ, McGrath KE, Frame JM, Palis J. Blood. 2011 Mar 3; 117(9):2708-17. Published on April 15th, 2011
  247. Comment on: Globin phenotype of erythroid cells derived from human induced pluripotent stem cells.By Chang KH, Huang A, Hirata RK, Wang PR, Russell DW, Papayannopoulou T. Blood. 2010 Mar 25; 115(12):2553-4. Published on September 15th, 2011

    Barbara Ghinassi

  248. Comment on: NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. By Miccio A, Wang Y, Hong W, Gregory GD, ..., Shelat S, Tong W, Poncz M, Blobel GA. EMBO J. 2010 Jan 20; 29(2):442-56. Published on June 10th, 2010

    Rosanna Botta

  249. Comment on: Direct conversion of human fibroblasts to multilineage blood progenitors. By Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, Fiebig-Comyn A, Levadoux-Martin M, Bhatia M. Nature. 2010 Nov 25; 468(7323):521-6. Published on January 3rd, 2011

Ilaria Ceglia

239. Comments on: A network including TGFβ/Smad4, Gata2, and p57 regulates proliferation of mouse hematopoietic progenitor cells. By Billing M, Rörby E, May G, Tipping AJ, Brown J, Salminen M, Karlsson G, Enver T, Karlsson S. Exp Hematol. 2016 May; 44(5):399-409.e5. PMID: 26876150 Published on April 6th, 2016

Publications for Italian Readership

  1. Varrichio L, Martelli F, Ciaffoni F, D’Amore E, and Migliaccio AR. Mielofibrosi Come Modello per lo Studio del Ruolo Del Microambiente Nello Sviluppo Delle Leucemie. Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY USA, Reports ISTISAN Rome, Italy, 2012 p.12-19
  2. Migliaccio AR., La medicina oltre la salute: Alla ricerca delle radici Salento Medico. 2012; 35 (6); 52 (30-33)