Foto del docente

Alessandro Ripalti

Adjunct Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Adjunct Professor

Department of Chemistry "Giacomo Ciamician"

Publications

1        Alvisi G, Roth DM, Camozzi D, Pari GS, Loregian A, Ripalti A, Jans DA. The flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells. J Virol. 2009 Sep;83(18):9567-76. Epub 2009 Jul 1. IF: 5.308

2        Alvisi G, Avanzi S, Musiani D, Camozzi D, Leoni V, Ly-Huynh JD, Ripalti A., Nuclear import of HSV-1 DNA polymerase processivity factor UL42 is mediated by a C-terminally located bipartite nuclear localization signal. Biochemistry. 2008 Dec 30;47(52):13764-77. IF: 3,368

3        Sinigalia E, Alvisi G, Mercorelli B, Coen DM, Pari GS, Jans DA, Ripalti A, Palù G, Loregian A. Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. J Virol. 2008 Dec;82(24):12574-9. Epub 2008 Oct 8. IF: 5.332

4        Alvisi G, Rawlinson, SM., Ghildyal R, Ripalti A, Jans DA. Regulated nucleocytoplasmic trafficking of viral gene products: a therapeutic target? Biochim Biophys Acta . 2008 Jan;1784(1):213-27. IF: 3.078

5        Alvisi G, Musiani D, Jans D, Ripalti, A An importin a/b-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus. Biochemistry . 2007 Aug 14;46(32):9155-63. IF: 3.848

6        Alvisi G, Ripalti A, Ngankeu A, Giannandrea M, Caraffi SG, Dias MM, Jans DA. Human cytomegalovirus DNA polymerase catalytic subunit pUL54 possesses independently acting nuclear localization and ppUL44 binding motifs. Traffic . 2006 Oct;7(10):1322-32. Epub 2006 Aug 15. IF: 6,612

7        Alvisi G, Jans DA, Ripalti A. Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus. Biochemistry . 2006 Jun 6;45(22):6866-72 . IF: 3.848

8        Alvisi G, Jans DA, Guo J, Pinna LA, Ripalti A. A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44 . Traffic . 2005 Nov;6(11):1002-13. IF: 6.4

9        Ricciardiello L, Baglioni M, Giovannini C, Pariali M, Cenacchi G, Ripalti A, Landini MP, Sawa H, Nagashima K, Frisque RJ, Goel A, Boland CR, Tognon M, Roda E, Bazzoli F.       Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res . 2003 Nov 1;63(21):7256-62. IF: 8.649

10     Muratori, L., E. Sztul, P. Muratori, Y. Gao, Ripalti A., C. Ponti, M. Lenzi, M.P. Landini, and F.B. Bianchi, Distinct epitopes on formiminotransferase cyclodeaminase induce autoimmune liver cytosol antibody type 1. Hepatology, 2001. 34:494-501 IF: 7.304

11     Maine, G.T., Stricker, R., Schuler, M., Spesard, J., Brojanac, S., Iriarte, B., Herwig, K., Gramins, T., Combs, B., Wise, J., Simmons, H., Gram, T., Lonze, J., Ruzicki, D., Byrne, B., Clifton, J.D., Chovan, L.E., Wachta, D., Holas, C., Wang, D., Wilson, T., Tomazic-Allen, S., Clements, M.A., Wright, G.L. Jr., Lazzarotto, T., Ripalti, A., Landini, M.P.  Development and Clinical Evaluation of a Recombinant-Antigen-Based Cytomegalovirus Immunoglobulin M Automated Immunoassay Using the Abbott AxSYM AnalyzerJournal of  Clinical Microbiology,  2000 Apr,  38(4): 1476-1481. IF: 3.503

12     Muratori, L., Parola, M., Ripalti, A., Robino, G., Muratori, P., Bellomo, G., Carini, R., Lenzi, M., Landini, M.P. Albano, E., Bianchi, F.B. Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane. Gut,  2000,  46: 553-561.  IF: 5.386

13     Battista, M.C., Bergamini, G., Boccuni, M.C., Campanini, F., Ripalti, A. and Landini, M.P. Expression and characterization of a novel structural protein of human Cytomegalovirus, pUL25. Journal of Virology,  1998,  73: 3800-3809. IF: 5.930

14     Santucci, M.A., Ripalti A., M.C. di Paola, A.M. Mianulli, E. Iacurti, F. Campanini, B. Gamberi, and S. Tura, Procedure for the quantitation of Gadd45 expression levels in clonal hematopoietic progenitor cells by competitive polymerase chain reaction. Clinical Biochemistry, 1999. 32:1-8. IF: 1.327

15     Boccuni, M.C., Campanini, F., Battista, M.C., Bergamini, G., Dal Monte, P., Ripalti, A., Landini, M.P. Human cytomegalovirus product UL44 downregulates the transactivation of HIV-1 long terminal repeat. AIDS,  1998,  12: 365-372.  IF: 8.018

16     Bergamini, G., Reschke, M., Battista, M.C., Boccuni, M.C., Campanini, F., Ripalti, A., and Landini, M.P. The major open reading frame of the beta 2.7 transcript of human cytomegalovirus: in vitro expression of a protein  posttranscriptionally regulated  by the 5' region. Journal of Virology,  1998,  8425-8429. IF: 5.930

17     Lazzarotto, T., Ripalti, A., Spezzacatena, P., Pradelli, P., Varani, S., Gabrielli, L., Battista, M.C., Campanini, F., Maine, G. and Landini, M.P. Development of a new Cytomegalovirus (CMV) IgM immunoblot for the detection of CMV-specific IgM.  Journal of Clinical Microbiology,  1998,  33: 3337-3341.  IF: 3.670

18     Meyer, H., Ripalti, A., Landini, M.P., Radsak, K., Kern, H.F., Hensel, G. Human Cytomegalovirus late phase maturation is blocked by stably expressed UL32 antisense mRNA in astrocytoma cells. Journal of General Virology,  1997,  78: 2621-2631. IF 3.126

19     Lazzarotto, T., Maine, G., Dal Monte, P., Ripalti, A., and Landini, M.P. A novel western blot test containing both viral and recombinant proteins for anticytomegalovirus immunoglobulin M detection. Journal of Clinical Microbiology,  1997,  35: 393-397. IF: 3.503

20     Battista, M.C., Bergamini, G., Campanini, F., Landini, M.P., Ripalti, A. Intracellular production of a major cytomegalovirus antigenic protein in the methylotrophic yeast Pichia pastoris. Gene , 1996,  176: 197-201.  IF: 2.461

21     Dal Monte, P., Bessia, C., Ripalti, A., Landini, M.P.  Topilko, A., Plachter, B., Verilizier, JL, Michelson, S. Stably-expressed antisense RNA to the Cytomegalovirus gene UL83 inhibits viral replicationJournal of Virology, 1996, 70: 2086-2094.  IF: 5.930

22     Dal Monte, P., Lazzarotto, T., Ripalti, A. and Landini, M.P. Human cytomegalovirus infection: a complex diagnostic problem in which molecular biology has induced a rapid evolution. Intervirology,  1996,  39: 139-144.  IF: 0,955

23     Ghisetti, V., Barbui, A., Lazzarotto, T., Donegani, E., Ripalti, A. Dal Monte, P. Marchiaro, G. and Landini, M.P. Comparison between virology and serology for the follow up of cytomegalovirus infection in heart transplant recipients. Serodiagnosis and Immunotherapy in Infectious Diseases, 1996, 8:43-50.

24     Landini M.P., T. Lazzarotto, G. Maine, A. Ripalti, and R. Flanders. Recombinant Mono- and Polyantigens to Detect Cytomegalovirus-Specific Immunoglobulin M in Human Sera by Enzyme Immunoassay. Journal of Clinical Microbiology, 1995, 33(10):2535-2542. IF: 3.503

25     Ripalti, A., Boccuni, M.C., Campanini, F. and Landini, M.P. Cytomegalovirus-mediated induction of antisense  mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: identification of an essential gene. Journal of Virology, 1995, 69:2047-2057. IF: 5.930

26     Ripalti, A., Boccuni, M.C., Campanini, F., Bergamini, G., Lazzarotto, T., Battista, M.C., Dalla Casa, B. and Landini, M.P. Construction of a polyepitope fusion antigen of human cytomegalovirus ppUL32 and detection of specific antibodies by ELISA. New Microbiol., 1995, 18:1-12.  IF: 0.422 

27     Ripalti, A., Ruan, Q., Boccuni, M.C., Campanini, F., Bergamini, G. and Landini, M.P. Construction of polyepitope fusion antigens of human cytomegalovirus ppUL32: reactivity with human antibodies. Journal of Clinical Microbiology,  1994,  32: 358-363.  IF: 3.503

28     Ripalti, A., Dal Monte, P., Boccuni, M.C., Lazzarotto, T., Campisi, B., Ruan, Q. and Landini, M.P. Procaryotic expression of a large fragment of the most immunogenic Cytomegalovirus DNA-binding protein and its reactivity with human antibodies. Journal of Virological Methods, 1994, 46: 39-50.  IF: 1.501

29     Lazzarotto, T., Dal Monte, P., Boccuni, M.C., Ripalti, A. and Landini, M.P.  Lack of correlation between virus detection and serologic tests for diagnosis of active Cytomegalovirus infection in patients with AIDS. Journal of Clinical Microbiology, 1992,  30: 1027-1029.  IF: 3.503

30     Landini, M.P., Lazzarotto, T., Percivalle, E., Ripalti, A., and G., Gerna, Evidence that Human Cytomegalovirus Assembly Protein Shares Antigenic Sites with an Uninfected Cell Membrane Protein. Journal of General Virology, 1991, 72:3009-3016. IF 3.126

31     Landini, M.P., Ripalti, A., Sra, K., and P., Pouletty, Human  cytomegalovirus structural proteins: Immune reaction  against pp150 synthetic peptides. Journal of Clinical Microbiology, 1991, 29: 1868-1872.  IF: 3.503

32     Lazzarotto, T., Boccuni, M.C., Dal Monte, P., Ripalti, A., Landini, M.P. Antigenic variation of cytomegalovirus isolates recovered from infected children. Microbiologica,  1991, 14: 239-249.  IF: 0.422

33     Ripalti, A.and E. S. Mocarski, The products of human cytomegalovirus genes UL1-UL7, including gp48, are dispensable for growth in cell culture. In Progress in Cytomegalovirus Research, 1991, M.P. Landini Ed., Elsevier Science Publishers, Amsterdam.

34     Landini, M.P., Guan, M.X., Jahn, G., Lindenmaier, W.,  Mach, M., Ripalti, A., Necker, A., Lazzarotto, T. and B., Plachter, Large scale screening of human sera with Cytomegalovirus recombinant antigens. Journal of Clinical  Microbiology, 1990, 28:1375-1379. IF 3.503

35     Landini, M.P., Trevisani, B., Guan, M.X., Ripalti, A., Lazzarotto, T., and M., La Placa, A simple and rapid procedure for the direct detection of cytomegalovirus in urine samples. Journal of Clinical  laboratory Analysis, 1990, 4:161-164. IF 0,991

36     Lazzarotto, T., Guan, M.X., Furlini, G., Re, M.C., Ripalti, A., Landini, M.P., and M. La  Placa, Relationship between  human immunodeficiency virus antigenemia and  cytomegalovirus infection.  Microbiologica, 1990, 13: 61-65.  IF: 0. 422

37     Landini, M.P., Lazzarotto, T., Ripalti, A., Guan, M.X., and M., La Placa, Antibody response to recombinant Lambda gt11   fusion proteins in Cytomegalovirus infection. Journal of Clinical Microbiology, 1989, 27:2324-2327. IF 3.503

38     Ripalti, A., Landini,M.P., Mocarski,E., and M., La Placa, Identification and preliminary use of recombinant lamdba gt11 fusion proteins in Cytomegalovirus diagnosis. Journal of  General Virology, 1989, 70:1247-1251. IF 3.126

39     Landini, M.P., Mirolo, G., Re, M.C., Ripalti,A., and M., La Placa, Antibody reactivity to Cytomegalovirus structural  polypeptides in subclinical and clinical human immunodeficiency virus infectionsEuropean Journal of  Clinical Microbiology, 1989, 8:159-163. IF 1.337

40     Ripalti, A., Trevisani, B., Landini, M.P. and M., La Placa, Diagnostic avail of a biotinylated DNA probe made from the  Xba I E fragment of human cytomegalovirus genome. Microbiologica,   1989, 12:1-6. IF 0.422

41     Ripalti,A. and Landini, M.P. (1988)  Human  cytomegalo ­virus-associated DNase and the specific immune response in   different clinical conditions. Biochemical Pharmacology, 1988, 37:1873-1874. IF 2.975

42     Landini, M.P., Baldassarri,B., Mirolo,G., Ripalti,A. and M., La Placa, Reactivity of cytomegalovirus structural  poly ­peptides with different subclasses of IgG present in human sera Journal of Infection, 1988, 16:163-167. IF 1.188

43     Ripalti,A., Landini,M.P., and M., La Placa, A 46 Kd  poly ­peptide, present in purified human cytomegalovirus, is provided with  DNase activity and is antigenically related  to a higher molecular weight, enzymatically inactive,  cellular protein.Microbiologica, 1988, 11:69-76. IF 0.422

44     Ripalti, A., Trevisani, B., Mirolo,G., Landini,M.P., and M., La  Placa, Construction of a biotinylated DNA probe for human cytomegalovirus and rapid detection of the virus in urine. In : Molecular probes :Technology and medical  applications, 1988, pp: 105-111, Raven press.

45     Ripalti,A. and Landini, M.P. (1988)  Human  cytomegalo­virus-associated DNase and the specific immune response in   different clinical conditions. Biochemical Pharmacology, 1988, 37:1873-1874. IF 2.975     

46     Mirolo,G., Baldassarri,B., Ripalti,A., Re,M.C.,  Clementi,M., Manzin,M. and M.P., Landini, Antibody response to individual Cytomegalovirus structural proteins in  different groups of subjects. European Journal of Clinical Microbiology , 1986, 6:207-210. IF 1.337

47     Furlini,G., Ripalti,A., Landini,M.P., and M., La Placa, Increased levels of ADP ribosylation during  Cytomegalovirus replication in human embryo fibroblasts. Microbiologica, 1984, 7:279-285. IF 0.422

48     Furlini, G., Coppolecchia,P., Re,M.C., Baldassarri,B., Ripalti,A. and M.P., Landini, In vivoeffectof novobiocin on primary cytomegalovirus infection. Journal of Antimicrobial Chemotherapy, 1983, 12: 503-506. IF 2,964

49     Landini MP, Ripalti A. A DNA-nicking activity associated with the nucleocapsid of human cytomegalovirus. Arch Virol. 1982;73(3-4):351-6. IF 1,47

50     Landini, M.P. and A. Ripalti, A DNA nicking activity associated with the nucleocapsid of human cytomegalovirus. Archives of Virology, 1982, 73:351-356. IF 1.705

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