Foto del docente

Alberto Leoni

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Publications

vai alle Pubblicazioni

Publications prior to 2004

M. Viale, C. Cordazzo, D. de Totero, R. Budriesi, C. Rosano, A. Leoni, P. Ioan, C. Aiello, M. Croce, A. Andreani, M. Rambaldi, P. Russo, A. Chiarini, D. Spinelli (2011) Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis INVESTIGATIONAL NEW DRUGS. vol.29 pp.98 - 109 ISSN:0167-6997


Andreani A., Burnelli S., Granaiola M., Leoni A., Locatelli A., Morigi R., Rambaldi M., Varoli L., Landi L., Prata C., Vieceli Dalla Sega F., Caliceti C., Shoemaker R.H (2010) Antitumor activity and COMPARE analysis of bis-indole derivatives BIOORGANIC & MEDICINAL CHEMISTRY. vol.18 pp.3004 - 3011 ISSN:0968-0896

A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, L. Varoli, M. A. Cremonini, G. Placucci, R. Cervellati, E. Greco (2010) New isatin derivatives with antioxidant activity EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. vol.45 pp.1374 - 1378 ISSN:0223-5234

S. Sparapani, S. Bellini, M. Gunaratnam, S.M. Haider, A. Andreani, M. Rambaldi, A. Locatelli, R. Morigi, M. Granaiola, L. Varoli, S. Burnelli, A. Leoni, S. Neidle (2010) Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif CHEMICAL COMMUNICATIONS. vol.46 pp.5680 - 5682 ISSN:1359-7345

A. Andreani, S. Bellini, S. Burnelli, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, L. Varoli, N. Calonghi, C. Cappadone, M. Zini, C. Stefanelli, L. Masotti, R.H. Shoemaker (2010) Substituted E-3-(3-Indolylmethylene)-1,3-dihydroindol-2-ones with Antitumor Activity. In Depth Study of the Effect on Growth of Breast Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY. vol.53 pp.5567 - 5575 ISSN:0022-2623

R.Gatti, M.G.Gioia, A.Leoni, A.Andreani (2010) 2,5-Dimethyl-1H-pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for HPLC/UV detection of amino acids JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. vol.53 pp.207 - 211 ISSN:0731-7085

R. Budriesi, P. Ioan, A. Locatelli, S. Cosconati, A. Leoni, M. P. Ugenti, A. Andreani, R. Di Toro, A. Bedini, S. Spampinato, L. Marinelli, E. Novellino, A. Chiarini. (2008). Imidazo[2,1-b]thiazole System: a Scaffold Endowing Dihydropyridines With Selective Cardiodepressant Activity. JOURNAL OF MEDICINAL CHEMISTRY. vol..51, pp 1592-1600

A. Andreani, A. Cavalli, M. Granaiola, M. Guardigli, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, M. Recanatini, A. Roda .(2001) Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindolinones and –pyrroles related to Donezepil. JOURNAL OF MEDICINAL CHEMISTRY vol. 44, pp 4001-4014.

A. Andreani, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, C. Pietra, G. Villetti. (2000) 4-aminopyridine derivatives with antiamnesic activity. EUR. J. CHEM. vol. 35, pp 77-82

P.G. Baraldi, B. Cacciari, A. Guiotto, R. Romagnoli, G. Spalluto, A. Leoni, N. Bianchi, G. Periotto, C. Rutiliano, C. Mischiati, R. Gambari. (2000) [2,1-c][1,4]Benzodiazepine(PBD)-Distamycin hybrid inhibits DNA binding to transcription factor Sp1. NUCLEOTIDES, NUCLEOTIDES & NUCEIC ACID vol. 19, pp 1219-1229

D. E. Thurston, D. S. Bose, P. W. Howard, T. C. Jenkins, A. Leoni, P. G. Baraldi, A. Guiotto, B. Cacciari, L. R. Kelland, M. P. Foloppe, S. Rault. (1999) Effect of A-Ring Modifications on the DNA-Binding Behaviour and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines. J. MED. CHEM., vol 42, pp 1951-1964

P.G. Baraldi, B. Cacciari, A. Guiotto, A. Leoni, R. Romagnoli, G. Spalluto, N. Momgelli, P.W. Howard, D.E. Thurston, N. Bianchi, R. Gambari,(1998) Design, synthesis and biological activity of a pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-Distamycin hybrid. BIORG. MED. CHEM. LET. vol 8, pp 3019-3024

A. Andreani, A. Leoni, M. Rambaldi, A. Locatelli, R. Bossa, M. Bissoli, Galatulas, M. Chliricozzi. (1997) Dihydropyridines bearing an imidazo[2,1-b]thiazole system. EUR.J.MED.CHEM. vol. 32, pp 151-157.

D.E. Thurston, D.S. Bose, A.S. Thomson, P.W. Howard, A. Leoni, S.J. Crocker, T.C. Jenkins, S. Neidle, J.A. Hartley, L. Hurley. (1996) Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand crosslinking agents. J. ORG. CHEM. vol 61, pp 8141-8147

A. Andreani, M. Rambaldi, A. Leoni, A. Locatelli, A.Ghelli, M. Ratta, B. Benelli, M. Degli Esposti. (1995) Thienylimidazo[2,1-b]thiazoles as Inhibitors of Mitochondrial NADH Dehydrogenase. J. MED. CHEM. vol. 38, pp 1090-1097.

P. G. Baraldi, A. Leoni, B. Cacciari, S. Manfredini, D. Simoni, M. Bergani, E. Menta, S. Spinelli. (1994) Synthesis and Antitumor activity of a new class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogues of Pyrrolo[1,4][2,1-c]benzodiazepines. J. MED. CHEM. vol. 37, pp 4329-4337

P.G. Baraldi, L. Garuti, A. Leoni, B. Cacciari, R. Budriesi, A. Chiarini. (1993) Synthesis and cardiodepressant activity of dialkyl-1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridinedicarboxylates. 2 DRUG DESIGN AND DISCOVERY vol. 10, pp. 319-329

P. G. Baraldi, A. Leoni, B. Cacciara, S. Manfredini, D. Simoni. (1993) Synthesis and Antitumor activity of a new class of Pyrazolo [4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of Pyrrolo[1,4]benzodiazepines. BIORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 3, pp. 2511-2514

P. G. Baraldi, R. Budriesi, B. Cacciari, A. Chiarini, L. Garuti, G. Giovanninetti, A. Leoni, M. Roberti. (1992). Synthesis and calciumantagonist activity of dialkyl-1,4-dihydro-2,6-dimethyl-4- (nitrogenousheteroaryl)-3,5-pyridine dicarboxylates. COLLECT. CZECH. CHEM. COMMUN. vol. 57, pp 169-178

Brevetto: "Heterocyclic analogues of pyrrolo[1,4]benzodiazepine with antitumoral activity" Cod. N. 04843650153 Date 4/8/1992 n. M192 A 0001913 P.G. Baraldi, A. Leoni.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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