The ratio between two circulating microRNAs can distinguish patients with inflammatory myopathies from other myo-related pathologies.
| Patent title | Diagnostic biomarker of inflammatory myopathies |
|---|---|
| Thematic area | Health |
| Ownership | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA, Azienda Ospedaliera- Universitaria di Bologna Policlino S. Orsola- Malpighi |
| Inventors | Rita Rinaldi, Miriam Capri, Roberta Costa, Cristina Morsiani, Giovanna Cenacchi |
| Protection | Italy (opportunity for seeking patent protection internationally) |
| Licensing status | Available for development agreements, option, license and other exploitation agreements |
| Keywords | Biomarker, Circulating microRNAs, Inflammatory myopathies, Rare disease, Diagnostic |
| Filed on | 17 May 2021 |
Currently, the diagnosis of inflammatory myopathy is rather complex, time-consuming and expensive, including blood tests, magnetic resonance and muscle biopsy, the latter invasive for the patient.
Diagnostic method based on circulating MicroRNAs able to provide a rapid and easy to analyze method to support the clinician. In particular, it has been identified an index given by the ratio between two MicroRNAs measured in plasma able to discriminate myositic patients from non-myositic ones, i.e. those patients affected by other muscle diseases that present with similar clinical manifestations.
The identified index can be used as non-invasive diagnostic marker of inflammatory myopathy, analyzing only these two circulating microRNAs in plasma sample, with further reduction of costs and time.