- Docente: Giorgio Milazzo
- Credits: 3
- SSD: BIO/18
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Rimini
- Corso: Single cycle degree programme (LMCU) in Pharmacy (cod. 9078)
Learning outcomes
By the end of the module, the student possesses knowledge of the fundamental principles of heredity; he is familiar with the nature, transmission, expression, variability and manipulation of the genetic information and can rigorously interpret and critically evaluate genetic experimental data.
Course contents
- Introduction to genetics
- Mendelian Genetics
- Gregor Mendel and basic principles of heredity; monohybrid crosses (dominance and segregation); dihybrid crosses (independent assortment)
- Predicting the outcome of genetic crosses; probability and Chi-Square test
- Cell division, mitosis and meiosis, chromosomal basis of inheritance
- Sexual reproduction, mitosis and meiosis.Chromosome theory of inheritance
- Sex determination and sex-linked inheritance
- Dosage compensation in mammals
- Human pedigree analysis
- Extensions and modifications of basic mendelian principles
- Allelic variation and gene function; why some alleles are dominant and other recessive; types of dominance, reduced penetrance, lethal alleles.
- Genetic heterogeneity, gene interactions and epistasis.
- Linkage, recombination, gene mapping in Eukaryotes
- Linked genes and crossing over; Constructing genetic maps with recombination frequencies
- Linkage analysis in human; DNA polymorphisms as genetic markers; the lod-score method
- Overview of genetics of bacterial and viral genetic systems
- Genetic variation, DNA repair and recombination
- Genetic variability; mutation and polymorphisms; types of genetic variants; molecular basis of mutations; point mutations and their consequences; mutagenesis
- DNA repair mechanisms; DNA recombination mechanisms
- Variation in chromosome number and structure; mechanisms of structural variation
Readings/Bibliography
Leland Hartwell, Michael L. Goldberg, Janice Fischer and Leroy Hood
6th edition
McGrawHill Education
Other textbooks:
Introduction to Genetic Analysis, by Griffiths, Wessler, Carroll, and Doebley.
Principles of Genetics , by D. Peter Snustad, Michael J. Simmons
Genetics. Analysis & Principles, by Robert J.Brooker
Concepts of Genetics, by Klug, Cummings, Spencer
Teaching methods
Lectures with powerpoint presentations; in class problem solving and exercise
Assessment methods
Final written and oral exam. Written will include multiple choice questions, questions with open answers and problem solving
Teaching tools
Course materials (ppt presentations, problems and solutions, suggested readings) will be made available to students
Office hours
See the website of Giorgio Milazzo