66201 - Advanced Organic Chemistry M

Learning outcomes

At the end of the course, the student is acquainted with and masters the following aspects: -Stereoselectivity in C-C bond forming reactions: definitions and applications. -How to represent 3D chiral molecular structures on a plane. -Reaction models enabling the rationalization of C-C bond forming reaction outcomes. Special focus is set on the stereochemistry of the transformations. -Asymmetric catalysis: basic principles and innovative applications, involving both metal (e.g. Lewis acids) and organic (e.g. proline and its derivatives) catalysts. -Application of the aforementioned concepts to the synthesis of structurally and stereochemically complex compounds.

Course contents

Prerequisites:

basic knowledge of organic chemistry: reactivity, notions of stereochemistry, reaction mechanisms.

Contents:

The course mainly deals with organic reactions for the creation of C-C bonds, with particular emphasis on the chemistry of enolates and asymmetric catalysis. The course also provides advanced knowledge on oxidation and reduction reactions in organic synthesis. Particular emphasis will be placed on the aspects of chemo-, regio- and stereoselectivity of the particular classes of reactions. The basic elements of retrosynthetic analysis for the synthesis design of important molecules will be presented. The course will take a mechanistic approach to understanding chemical reactions.

Readings/Bibliography

Pdf slides in English are provided by the teacher  through the website https://iol.unibo.it/

Teaching methods

Frontal lectures and exercises on the blackboard

Assessment methods

The final exam consists of an oral exam in which exercises related to the topics covered in the lessons are performed.

Teaching tools

Frontal lectures with possible video projection aid. Students with specific learning disabilities or disabilities can contact the Student Services for Disabilities and DSA of the University of Bologna (http://www.studentidisabili.unibo.it/) and the contact person of the Department (giorgio.bencivenni2@unibo.it) or the teacher of the course to agree on the most suitable ways to consult the teaching material and access the classrooms for the frontal lessons.

Office hours

See the website of Giorgio Bencivenni