82678 - Problem Oriented Approach: Good Use of Antimicrobials in Animal Farming

Learning outcomes

Learning outcomes

The first aim of the Course “Problem oriented approach: good use of antimicrobials in breeding animals” is to provide students with useful information on the prudent use of antimicrobials in veterinary medicine and to better know and understand the EU Guidelines on this topic (2015/C 299/04). The Guidelines mention “Antimicrobial resistance (AMR) is therefore a priority for the Commission. In November 2011, it launched a five-year action plan designed to address the growing risks posed by AMR (1). The action plan is based on a holistic approach, in line with the ‘One Health’ perspective. It involves participation from all sectors and covers all aspects of AMR. The main aims of the plan are to strengthen the prevention and control of AMR across the human, veterinary and food sectors and to secure the availability and prolong the effectiveness of antimicrobial agents. The action plan covers seven areas and sets out twelve specific actions to be taken in the human and/or veterinary fields”.

By the end of the Course, the student should have acquired:

• Knowledge on the ‘One Health’ perspective;

• Knowledge on the purpose of antimicrobial treatments (prophylaxis, metaphylaxis, therapy);

• Knowledge on the applicability limits in the off-label use of antimicrobials in food producing species;

• Knowledge on the “Critically Important Antimicrobials for Human Medicine” and the development of resistance to substances other than antimicrobials;

• Knowledge on the molecular bases being responsible of the acquisition and dissemination of antibiotic resistance characters between animals, environment and food-borne sources;

• Analytical skills to check the qualitative presence of antimicrobials in food of animal origin;

• Analytical skills to evaluate qualitatively (antibiogram) and quantitatively (MIC) the resistance in microorganisms of zoonotic interest;

• Analytical skills of genomics techniques to study antibiotic resistance in food producing animals and in food of animal origin;

• Knowledge on how to find, analyse and choose the best and more useful information provided by scientific literature, as well as by Guidelines, Rules, and Regulations.

• LEARNING ABILITY, INDEPENDENT JUDGEMENT, COMMUNICATION SKILLS - the student should be able to:

• Find the link between different but connected subject matters;

• Demonstrate to have a reasoned and critical approach to the subject matter, rather than rote-learned knowledge;

• Discuss the topics of the Course.

Course contents

Presentation and aims of the course

This Course will allow the student to obtain knowledge on the main principles of the prudent use of antimicrobials in veterinary medicine, and more specifically in food producing animals. Basic information on antimicrobial products (i.e. SPC), on kinetics and on their proper administration (i.e. dosage, intervals of administration, duration of the therapeutic protocol) will be discussed.

Moreover, the Course will underline some important general aspects that need to be taken into consideration when administrating antimicrobials in food-source animals, especially in order to ensure the safety of the food production chain and to be aware of the antimicrobial resistance issue. Concerning antimicrobial resistance the prudent use of antimicrobials will be discussed, insisting on the importance of taking samples and performing antimicrobial susceptibility testing, and finally realizing the impact that antimicrobial resistance and antibiotics may have on the environment.

The use of a “self-directed learning” approach, in terms of teamwork and personal investigation, represents the main teaching innovation of this Course. The student will also learn how to discuss specific topics properly using the tools that are available to gather relevant information, building awareness and decision-making autonomy.

Readings/Bibliography

Teaching material

Considering the organization of the course, the student will have to research for the material under the teacher’s indications (i.e. scientific papers and reviews, textbooks, Guidelines, Rules, and Regulations); these will be needed for the work during the lessons.

Specific textbooks will be recommended.

Syllabus

A syllabus will be built and will be available through the University website (http://campus.cib.unibo.it).

Teaching methods

Teacher

The Course will be held by Professor Anna Zaghini (“Bases for the correct use of antimicrobials”) and by Professor Gerardo Manfreda and Dr Frederique Pasquali (“Genomics and traditional techniques to study antibiotic resistance”).

The teaching may involve postgraduate research staff of the Department of Veterinary Medical Sciences. During the Course, several lectures might be organized with the collaboration of external teachers being experts on specific subjects.

Teaching methods and lesson format

The course consists of 48 hours of frontal lessons/lectures and is divided into two modules: “Bases for the correct use of antimicrobials” (4 CFU, 32 h) and “Genomics and traditional techniques to study antibiotic resistance” (2 CFU, 16 h). The first module provides mainly lectures, but classroom lessons are also intended to encourage close interaction between the teachers and the students. This is aimed to prompt the students to appreciate the links between the treated matters, stimulate a reasoned approach and an independent work of small groups of students ending with a final presentation (power point) of the student’s work. The second module consists mainly in practical laboratory work, learning how to evaluate the acquisition and dissemination between animals-environment-food of animal origin of antibiotic resistance character in pathogenic microorganisms of zoonotic interest. In more detail, methods for the qualitative and quantitative assessment of the phenotypic (MIC and antibiogram) and genotypic (Real-Time PCR, Whole Genome Sequencing) traits of antibiotic resistance will be applied, as well as methods to study their possible diffusion. Methods to check the qualitative presence of antimicrobials in food of animal origin will also be considered.

Assessment methods

Student assessment methods

The final exam will be a short written test with multiple choice questions. The final grade will take into account also the student's participation in the group work, class discussions and the practical activities carried out in the laboratory.

How to enrol in examinations and the examination calendar

Students may sign up for the examination through the AlmaEsami online system. For further enrolment instructions, please go to: ( https://almaesami.unibo.it/almaesami/welcome.htm ).

Examination dates appear in special windows for students in line with the course schedule, while are listed throughout the year for students behind in the course schedule.

• When the number of candidates enrolled for an examination is too high, the examining committee will ensure the examination of the at the first possible opportunity.

• Students may not enrol in more than one examination date at a time.

• Students failing the oral examination are entitled to re-take the test after a minimum period of three weeks.

Teaching tools

Video player to show power point slides; clickers may be used.

Office hours

See the website of Anna Zaghini

See the website of Gerardo Manfreda