- Docente: Claudia Testa
- Credits: 6
- SSD: FIS/07
- Language: Italian
- Moduli: Claudia Testa (Modulo 1) Leonardo Brizi (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Physics (cod. 8025)
Learning outcomes
At the end of the course the student will have a incisive knowledge of physics basics and of experimental procedures which are at the basis of important medical implementations. In particular, the student will learn advanced diagnostic techniques based on morpholgic, functional images and radiotherapic techniques and he will be able to use softwares for simulation of acquisitions and for inversion of multi-exponential NMR data.
Course contents
Physical basis of Nuclear Magnetic Resonance (NMR) - Time Domain NMR (TD-NMR). Relaxometry - Relaxation times and molecular motion. Blembergen, Purcell, Pound theory- Surface effects - Relaxation times in biological tissues - Inversion from data time domain to relaxation times - UPEN algorithm and UpenWin software - Ex situ analyses. Imaging (MRI) spin-warp method - k-space and k-space mapping- PERFIDI filters.
In vivo Magnetic Resonace Spectroscopy. Chemical shift. j-coupling. Single voxel (SV) and Chemical shift Imaging. Post Processing. Relative and absolute quantification. Artifacts. Brain 1H-MRS. Heteronuclear spectroscopy. Diffusion weighted/Diffusion Tensor imaging. Tractography, whole brain tractography. Structural connectivity.
Functional MRI. Block design. Resting state fMRI. Post processing. Functional connectivity
X rays- X rays production - Interactions photons-matter. CT scanners - photon energy for medical CT- beam hardening. Hounsfielf units - Applications.
SPECT – PET- physical basis- Applications.
Radiotherapy – LINAC - Adrotherapy. Bragg peak- Applications.
Ultrasounds in medicine
Readings/Bibliography
Callaghan, Principles of MRMicroscopy e sito online di Hornak;
In Vivo NMR Spectroscopy: Principles and Techniques, 2nd Edition Robin A. de Graaf
Functional Magnetic Resonance Imaging. An Introduction to Methods Edited by Peter Jezzard, Paul M Matthews, and Stephen M Smith
R. Zannoli e C. Orsi, Elementi di Strumentazione Medica, Società Editoriale Esculapio (1999)
M. Marengo, La Fisica in Medicina Nucleare, Patron Editore, Bologna, (2006)
Teaching methods
Classrooms lessons.
Assessment methods
Oral examination, after discussion of scientific reports on data analysis, based on the application of dedicated algoritms and softwares elucidated during the lectures.
Teaching tools
Use of softwares for data simulations and data inversion (2 CFU)
Office hours
See the website of Claudia Testa
See the website of Leonardo Brizi