Treatment of neurodegenerative diseases

Novel triazinone derivatives and their use as therapeutic agents to treat a variety of neurodegenerative disorders, including Alzheimer’s disease.

Patent title Dual Inhibitor Compounds for Use in the Treatment of Neurodegenerative Disorders and Alzheimer's Disease
Thematic area Health
Ownership ISTITUTO ITALIANO DI TECNOLOGIA - sede di Genova, ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA
Inventors ANGELO FAVIA, FEDERICA PRATI, GIOVANNI BOTTEGONI, DANIELA PIZZIRANI, RITA SCARPELLI, Maria Laura Bolognesi, Andrea Cavalli
Protection International application
Licensing status Available for development agreements, option, license and other exploitation agreements
Keywords Triazinone, Derivatives, Neurodegenerative, Disorders, Alzheimer’s disease (AD)
Filed on 13 June 2014

AD is a progressive neurological disorder characterized by deterioration of cognitive function, dementia, memory loss, and altered behavior. Multitarget drugs (MTDs), namely small organic molecules able to hit multiple targets belonging to different pathological pathways, are emerging as promising disease-modifying compounds for the treatment of complex neurological disorders.

Synthesis of new derivatives of triazinone and their use as therapeutic agents to treat a variety of neurodegenerative disorders, including Alzheimer's disease (AD).

The aim of the present invention is therefore to provide novel compounds having a large spectrum of neuroprotective and anti-neurodegenerative properties and able to be effective in the treatment of AD. In particular, one of the aim of the present invention is to provide novel compounds having inhibitory activity against BACE-1 and GSK-3β demonstrating an increased neuroprotective and neurogenesis activity to treat Alzheimer’s disease.

  • Simplified therapeutic regimen
  • Improved compliance
  • Improved efficacy due to the synergistic effect of simultaneously inhibiting multiple targets
  • Improved safety by decreasing the side effects related to the load of a drug cocktail
Page published on: 05 March 2015