PhD in Oncology, Hematology and Pathology

Academic Year 2019-2020
Subject area Medical, Pharmaceutical and Veterinary Medical Sciences
Cycle 35
Coordinator Prof.ssa Manuela Ferracin
Language English, Italian
Duration 3 years
Positions 29 positions. More information in the PhD Programme Table.
Application deadline May 15, 2019 at 01:00 PM (Expired)
Enrolment period From Aug 01, 2019 to Aug 26, 2019
Doctoral programme start date Nov 01, 2019
Operating centre
Main Department
Department of Experimental, Diagnostic and Specialty Medicine - DIMES
Mobility abroad
Yes (3 months)
Research topics

Solid and hematological neoplasms. Palliative medicine. Immunoprevention and immunotherapy of tumors. Oncology, genomics, proteomics and targeted therapy of musculoskeletal sarcomas. Development of new therapies in pediatric onco-hematology, (neuroblastoma, acute myeloid leukemia, leukemias and lymphomas of B cells). Radiotherapy, oncological radiodiagnostics, radiomics and radiobiology. Rare tumors. ERBB family receptors. Resistance to targeted therapies. Acute and chronic myeloproliferative syndromes. Lympho(immuno) proliferative diseases, monoclonal gammopathies and multiple myeloma. Molecular basis and genetic studies of leukemias, lymphomas and multiple myeloma. Research and development of innovative and targeted drugs against adult oncohemopathies (acute and chronic leukemias, lymphomas and multiple myeloma). Molecular pathology of infections associated with implants: search of virulence factors of opportunistic microorganisms as etiologic agents of periprosthetic infections and pathogenic mechanisms. Predictive biomarkers of osteoporosis and of idiopathic scoliosis. Plant toxins with N-glycosilase activity: mechanisms of cytotoxicity and immunotargeting. Alterations of protein glycosylation in pathological processes. Changes in ribosome biogenesis, cell proliferation and tumorigenesis. Immunology, genetics and epigenetics of aging, longevity and age-associated diseases. Allelic polymorphisms to identify risk factors associated with dementia and Alzheimer disease. Chronic pain. Omic data analysis. Genetic and epigenetic alterations as cancer diagnostic or prognostic biomarkers. Role of non-coding RNA in human cancer. Shiga toxin and hemolytic uremic syndrome. Human genomics and transcriptomics in normal conditions and in genetic disorders. Stem cells, differentiation and development.

Job opportunities and potential areas of employment
Our PhDs find employment in public and private research institutions, both national and international (mainly European and U.S.), in the healthcare system, including national research and care institutes (IRCCS) and in private laboratories and clinics.
Admission Board

Surname Name Institution Role e-mail
Pantaleo Maria Abbondanza Università di Bologna member
Salvioli Stefano Università di Bologna member
Soverini Simona Università di Bologna member
Manfrini Olivia Università di Bologna representative of a financing body (Fondazione Donato-Venturi)
Brigotti Maurizio Università di Bologna substitute
Foschini Maria Pia Università di Bologna substitute
Zamagni Elena Università di Bologna substitute
Learning outcomes
The learning goals of the Ph.D. Program are as follows:
- We develop graduates with advanced knowledge of literature and theory in the fields of Oncology, Hematology and Pathology
- We develop graduates with theoretical and practical knowledge of advanced research skills
- We develop graduates capable of producing original research of quality appropriate for publication in high-impact scholarly journals
- We develop graduates capable of producing translational research that applies to clinical challenges the avanced knowledge originating from laboratory research.
Activities to be carried out by Doctoral candidates
The activity is largely devoted to translational and clinical research in the fields of oncology, hemathology and pathology. The activities include research in the laboratory, field research, clinical research, and the use of large advanced equipment in the field of molecular biology and genetics. The PhD program therefore directs towards preclinical and clinical research applications and offers wide opportunities to trainees to develop their activities in centers of scientific and clinical excellence.
Research training activities compliant with the Doctoral programme's learning outcomes
The PhD program includes laboratory and/or clinical research activities, organized by the Supervisor of each PhD student, and teaching activities organized by three - The pool of medical PhD Programs organizes courses of scientific English (24 hours, in collaboration with Centro Linguistico d’Ateneo) and courses on safety in the biomedical environment (12 hours, in collaboration with the Area Persone e Organizzazione of the University and with the safety managers of the medical Departments)
- The PhD program organizes seminars by faculty members. Main subjects are: Biology and pathology of the cell cycle, Cell death and apoptosis, Mechanisms of cytotoxicity of Ribosome Inactivating Proteins, Genetic variants involved in longevity or age-associated diseases, Cytokines in human disease, Glycobiology and glycopathology, Molecular and cellular oncology, Carcinogenesis, Tumor immunology and immunotherapy, Diagnosis of hematopoietic and solid tumors, Cancer epidemiology and prevention, Conventional and innovative therapy of tumors, Palliative medicine, Biopathology and treatment of lymphomas, myeloma and acute leukemias, Allogeneic/autologous stem cells transplantation, New molecular technnologies for the study of hematologic malignancies
- Each Supervisor coordinates the attendance of specific events (meetings, workshops, grand rounds, etc.) and provides advanced bioinformatical education and tools in relation to the specific research project of each PhD student.
Internationalization features
- International experience. All Ph.D. students must attend research laboratories abroad in major research institutions, for at least 3 months.
- Attraction of foreign graduates (5 Marie Curie at present).
- National and international networks of PhD. The PhD is part of the network of the Istituto Superiore di Oncologia (ISO). This network organizes the international education in molecular oncology of graduates wishing to undertake or continue research in this specific field. The ISO network brings together 15 Italian Universities, including the Universities of Naples "Federico II", Genoa, Padua, Bologna, Pisa and Turin. International partners of this network include all the major oncological institutions worldwide. All network partners have a recognized expertise in various aspects of oncology and/or molecular endocrinology. The network has the purpose of mutual recognition of the formative period of research at partner institutions. Further international exchanges are based on the scientific networks of all members of the PhD faculty.
Expected research results and products
Papers published in international journals, indexed in PubMed (at least one full paper per PhD student during the PhD course, or within 2 years after the end of PhD), and oral/poster communications at national and international scientific meetings. Also, patents resulting from translational research and clinical protocols resulting from clinical research.
Doctoral programme Academic Board
Surname Name University/Institution Qualification
ARCIOLA CARLA RENATA Università di Bologna Professore Associato
ARDIZZONI ANDREA Università di Bologna Professore Ordinario
BOLOGNESI ANDREA Università di Bologna Professore Associato
BRANDI GIOVANNI Università di Bologna Professore Associato
BRIGOTTI MAURIZIO Università di Bologna Ricercatore
CAVO MICHELE Università di Bologna Professore Ordinario
DALL'OLIO FABIO Università di Bologna Professore Associato
DONATI DAVIDE MARIA Università di Bologna Professore Associato
FERRACIN MANUELA Università di Bologna Professore Associato
FOSCHINI MARIA PIA Università di Bologna Professore Ordinario
GARAGNANI PAOLO Università di Bologna Ricercatore
LAURIOLA MATTIA Università di Bologna Ricercatore
LOLLINI PIER LUIGI Università di Bologna Professore Ordinario
MONTANARO LORENZO Università di Bologna Professore Associato
MORGANTI ALESSIO GIUSEPPE Università di Bologna Professore Ordinario
NANNI PATRIZIA Università di Bologna Professore Associato
PANTALEO MARIA ABBONDANZA Università di Bologna Professore Associato
PELLERI MARIA CHIARA Università di Bologna Ricercatore
PESSION ANDREA Università di Bologna Professore Ordinario
SALVIOLI STEFANO Università di Bologna Professore Associato
SOVERINI SIMONA Università di Bologna Ricercatore
ZAMAGNI ELENA Università di Bologna Ricercatore
ZINZANI PIER LUIGI Università di Bologna Professore Ordinario