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28994 - Fundamentals of Biochemical Engineering

Academic Year 2018/2019

                
                        Docente:
                        Cristiana Boi
                    
                        Credits:
                        6
                    
                        SSD:
                        ING-IND/24
                    
                        Language:
                        Italian
                    
                        Moduli:
                        
                            Carlo Gostoli
                            (Modulo 1)
                        
                            Cristiana Boi
                            (Modulo 2)
                        
                        Teaching Mode:
                        
                                    Traditional lectures (Modulo 1)
                                
                                    Traditional lectures (Modulo 2)
                                
                            Campus:
                            Bologna
                        
                            Corso:
                            Second cycle degree programme (LM) in
                            Molecular and industrial biotechnology (cod. 9213)

                            Teaching resources on Virtuale

Learning outcomes

Basic knowledge and modelling of physical–chemical phenomena involved in the biochemical processes at industrial level.

Course contents

Peculiar features of biochemical processes. Batch, continuous and fed-batch operations. Steady and non-steady state.
Fluid dynamics, laminar and turbulent flow, Newton’s low and viscosity, non-newtonian fluids. Bernoulli’s equation, head loss, friction factor.
The different methods to describe the composition of a mixture.
Mass balance for a non reacting system in steady and non steady state.
Phase equilibrium, mass balance for a single equilibrium stage and for counter-current cascade.
Mass balance for reacting system, reaction rate, examples (first order, Michaelis–Menten, exponential growth, …).
Continuous flow reactors: the ideal stirred tank reactor and the ideal plug flow reactor, tanks in series, mass balance and analysis of isothermal reactors.
Overall mass transfer coefficients.
Mass transfer coefficients in the single phases, the resistance in series concept, reactions between a fluid and a solid, controlling step, aeration of bioreactors.
Diffusion: Fick’s law, diffusion in gas, liquid and solids. Steady state and transient diffusion in plane, cylinder, spheres, some applications: barrier polymers, membranes.
Mass transfer in laminar and turbulent flow: film theory, dimensional analysis, empirical correlations.
Heat transfer mechanisms, steady state conduction and convection. Transient heat transfer, analogies among mass and heat transfer.
Energy balance. Some remarks on the first principle of thermodynamics. Energy balance for open systems, applications.

Readings/Bibliography

Gostoli C., Trasporto di materia con elementi di reattoristica chimica e biochimca, Pitagora editrice, Bologna, 2011.
Cussler E.L., Diffusion, Mass Transfer in Fluid System, Cambridge University Press, 1984.
R.G. Harrison, P. Todd, S.R. Rudge, D. P. Petrides, Bioseparations Science and Engineering, Oxford Univ. Press, 2003.
Y.A. Çengel, Termodinamica e trasmissione del calore, McGraw-Hill, 3a Ed., Milano (2009).

Teaching methods

Class lectures, homework problems, discussions of the solutions.

Assessment methods

Written examination, an oral (optional) integration maybe possible.

Office hours

See the website of Cristiana Boi

See the website of Carlo Gostoli