54744 - Drug Science

Course Unit Page

SDGs

This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.

Good health and well-being

Academic Year 2018/2019

Learning outcomes

At the end of the course,the student has skills on the fundamental principles that govern the development of the drug. In particular, the student is able to: - plan projects for development of an innovative drug for a disease important for a global market- carry out a comparative evaluation between public spending and the potential benefits of treatment with drugs

Course contents

Development of a conventional drug


Tools, in vitro, in vivo and in silico systems


Preclinical development, drug discovery


Preclinical pharmacokinetics, from animal to man


Experimental models in preclinical studies


Safety pharmacology 


Safety preclinical studies


Asymmetry: non-genetic effects in preclinical development


Clinical trials (Phase I,II and III)


Clinical Research Associate


Registration dossier and leaflet


Marketing authorization procedures


Pharmacovigilance


Development of Biological drug

Development of Anticancer drug 

Readings/Bibliography

Texts suggested: L.M. Fuccella, E. Perucca, C. Sirtori - Farmacologia clinica - Casa Editrice UTET, Torino , E. Hogdson - Tossicologia moderna - Casa Editrice EDISES, P. Dolara - Farmacologia e tossicologia sperimentale - Pitagora Editrice, Bologna. A. Wallace, A. Hayes - Principles and methods of toxicology - Raven Press, New York.

Teaching methods

The course is divided into lectures, seminars and discussion. Class attendance is not mandatory but strongly recommended for a better learning of the subject. The exercises in the laboratory will be carried out by dividing the students into various groups (from 10 to 15), each of which will be dedicated to the same period of exercise. The exercises will be carried out at the end of the lectures and are mandatory, at least 2/3.

Assessment methods

The exam is a written test (2 hours) during which is not allowed the use of books, notes and electronic media and a subsequent short oral examination when necessary. The test aims to verify the knowledge of the subject matured by the student who, together with his critical capacity, will determine positive evaluations. Lack of orientation in the topics covered during the course, training gaps and inappropriate language, including purely grammatical errors, will result in negative evaluations. The vote obtained will be used, in agreement with the Hygiene teaching, for the calculation of the weighted average which will constitute the final mark of the Integrated Course.

Teaching tools

PC computer projector
Distribution of the material projected during the lesson

Office hours

See the website of Moreno Paolini