- Docente: Pierluigi Strippoli
- Credits: 9
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)
Course contents
Gene and Genome
00. introduction to genetics. History of Genetics.
01. Molecular structure of DNA and genetic information.
02. Gene: concept, structure and function. Evolution of trhe concept of "gene" and "code". Alternative ways of gene functioning.
03. Genome.
04. Gene families.
05. Tandem repeats.
06. Dispersed repeats (LINE, SINE, LTR and DNA transposons).
Leggi dell'Eredità
07. Human karyotype.
08. The experiments of Mendel. Dominance, recessivity, homozygosis and heterozygosis.
09. Autosomic dominant inheritance.
10. Autosomic recessive inheritance.
11. Codominance. ABO system. Substance H and Bombay phenotype.
12. Rh system. Maternal-fetal incompatibility for the Rh blood group.
13. Genetic determination of sex. X and Y chromosomes.
14. Sex-linked inheritance. X-chromosome inactivation.
15. Linkage and crossing-over.
16. Mitochondrial inheritance.
17. Epigenetics.
Variabilità genetica
18. Mutazion.
19. Effects of gene mutation.
20. Chromosome structure mutations.
21. Translocations.
22. Genomic mutations. Trisomy 21.
Eredità multifattoriale
23. Multifactorial inheritance.
24. Multifactorial traits.
Genetica di popolazione
25. Law of Hardy-Weinberg.
26. Forces affecting the Hardy-Weinberg equilibrium.
Readings/Bibliography
Text in preparation.
Assessment methods
Oral exam.
Teaching tools
http://apollo11.isto.unibo.it/appunti.htm
Links to further information
http://apollo11.isto.unibo.it/Medicina/Genetica_2/Genetica.htm
Office hours
See the website of Pierluigi Strippoli