- Docente: Giuseppe Gasparre
- Credits: 1
- SSD: MED/03
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)
Learning outcomes
Course contents
- Mitochondrial DNA: structure,
replication, transcription and translation. Mitochondrial
genetics.
- Aerobic glycolysis vs. respiration: the metabolism of solid
neoplasms.
- Metabolic tumor suppressor genes and relevance in cancer
progression.
- Mitochondrial DNA mutations within tumor genesis and cancer
progression.
- Oncocytic neoplasias: the importance of mitochondrial
metabolism in cancer.
Readings/Bibliography
Mitochondria and cancer. Wallace DC. Nat Rev Cancer. 2012 Oct;12(10):685-98. doi: 10.1038/nrc3365.
Mitochondrial mutations in cancer. Brandon M, Baldi P, Wallace DC. Oncogene. 2006 Aug 7;25(34):4647-62. Review.
Mitochondria and cancer: Warburg addressed. Wallace DC. Cold Spring Harb Symp Quant Biol. 2005;70:363-74. Review.
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Wallace DC. Annu Rev Genet. 2005;39:359-407. Review.
Complex I impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes. Iommarini L, et al. Int J Biochem Cell Biol. 2012 Jun 2.
Learning from oncocytic tumors: Why choose inefficient mitochondria? Gasparre G, et al. Biochim Biophys Acta. 2011 Jun;1807(6):633-42. Epub 2010 Aug 21. Review.
A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells.Icard P, Lincet H. Biochim Biophys Acta. 2012 Dec;1826(12):423-33. doi: 10.1016/j.bbcan.2012.07.001.
Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA. Pohjoismäki JL, Goffart S. Bioessays. 2011 Apr;33(4):290-9. doi:10.1002/bies.201000137. Epub 2011 Feb 2.
Mitochondrial DNA transcription regulation and nucleoid organization. Rebelo AP, Dillon LM, Moraes CT. J Inherit Metab Dis. 2011 Aug;34(4):941-51. Epub 2011 May 4. Review.
Teaching methods
Lectures
Assessment methods
Multiple choice test. The test poses 6 different questions with three possible answers one of which only is correct. The test is passed by answering correctly to three of the six questions.
Teaching tools
Powerpoint slides
Scientific papers
Office hours
See the website of Giuseppe Gasparre