- Docente: Giuseppina Di Stefano
- Credits: 6
- SSD: MED/04
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in School of Dentistry (cod. 8204)
Learning outcomes
Knowledge of the etiology and of the the pathogenetic mechanism of human diseases. Study of the morphological changes induced by diseases in tissues and of their functional consequences for the organism.
Course contents
Introduction to the study of General Pathology
OEDEMA
The microcirculation and the Starling hypothesis; Fluid transudation and exudation; Pathogenesis of localized and generalized oedema.
INFLAMMATION
Cells of inflammation; Chemical mediators of inflammation; Cardinal signs of inflammation; Phagocytosis and the bactericidal mechanism of leukocytes; Different types of exudate; Function of exudate; Features of chronic inflammation: granulation tissue, ulcers, abscesses, granulomas, fibrosis; Wound healing; Fever and other systemic effects of inflammation.
IMMUNITY
Antigens; Antigen receptors: antibodies, major
histocompatibility complex, antigen receptor on T lymphocytes;
Antigen processing and presentation to CD4 and CD8 T lymphocytes;
Maturation of lymphocytes; Genetics of antibodies; Activation of
lymphocytes; Mechanisms of humoral immunity; The complement
system; Mechanisms of cell-mediated immunity; Immunopathologic
reactions: anaphylaxis, antibody-mediated cytotoxicity,
immune-complex diseases, delayed hypersensitivity; Immune tolerance
and autoimmune diseases. Oral mucosa immunity.
ONCOLOGY
Definition and nomenclature of tumours; Epidemiology of tumours; Genetic predisposition to neoplasm; Genetics of neoplasm: “caretaker” and “gatekeeper” oncosuppressor genes, oncogenes; Morphologic and biochemical features of tumour tissues; The process of carcinogenesis and the tumour growth; Tumour angiogenesis; Metastasis; Carcinogenic agents and their mechanism of action.
HEMODYNAMIC DISORDERS
Atherosclerosis; Thrombosis; Embolism; Infarction and
ischemia-reperfusion pathology; Oral mucosa infections and
cardiovascular disease.
Readings/Bibliography
- Vinay Kumar, Abul K. Abbas, Nelson Fausto
Robbins e Cotran. Le basi patologiche delle malattie PATOLOGIA GENERALE
Elsevier-Masson
- V. Kumar, AK Abbas, JC Aster
EDRA
Immunology textbook:
- Peter Parham
Il sistema immunitario
EdiSES
Teaching methods
The course consists of about 50 hours of lessons
Assessment methods
The final exam will be conducted orally and will aim to verify the achievement of educational objectives; more specifically, it will assess the student's knowledge of the basic mechanisms through which human diseases are generated. The student will be asked to discuss in depth two of the topics covered during the teaching course.
The final grade of the General Pathology course is the average of the grades obtained in the tests of General Pathology and Laboratory of General Pathology.
Teaching tools
Use of personal computer; slide showing.
Office hours
See the website of Giuseppina Di Stefano