27868 - Laboratory of Organic Synthesis and Characterization

Course Unit Page

Academic Year 2017/2018

Learning outcomes

Objective of the course is to develop basic skills in the synthesis of organic compounds by modern synthetic methods. The student will be able to analyze and purify substances by liquid chromatography. The student will develop basic skills in  the identification of simple organic compounds through combined NMR, MS, IR and UV spectra.

Course contents

Grade and safety information of organic reagents, solvents and commercial details. Reactions involving air and moisture sensitive reagents, Schlenk line and syringe techniques. Purification procedure of organic compounds by column chromatography. Acquire practice and techniques in organic synthesis by multistep synthesis.

Introduction to mass spettrometry for simple organic compounds, electron impact and electronspray spectra. Application of UV spectroscopy to organic chemistry. Nuclear Magnetic Resonance: chemical shifts in H-1 and C-13 NMR for the main class of organic compounds. Spin systems and Pople notation, Karplus equation in H-1 NMR. Interpretation of spectroscopic data for the identification of simple organic compounds by NMR, IR and MS and UV combined spectra.

Readings/Bibliography

Lecture Notes.

Electronic presentations on AMS Campus.

Recommended Books:

M. D'Ischia,   La Chimica Organica in Laboratorio,   Piccin editore (2002)

Mayo, Pike, Forbes,  Microscale organic laboratory, Wiley

Leonard, Lygo, Procter, Advanced practical organic chemistry, Thorner Ed.

Keese, Braendel, Toube, Practical organic synthesis, Wiley

J.W.Lehman, Operational Organic Chemistry ,   Prentice Hall

Teaching methods

Oral lectures supported by multimedia techniques. Laboratory sessions to improve experimental skills in organic synthesis and characterization. Training in the interpretation of laboratory data and in writing laboratory report will be arranged.

Assessment methods

To pass the exam a candidate must have a positive evaluation in  three parts:  laboratory reports, written test on the identification of a simple organic compound by combined H-1, C-13 NMR, IR, MS spectra, and a viva voce.

Teaching tools

Oral lectures were supported by multimedia techniques. Laboratory sessions to improve experimental skills will be in the organic synthesis  laboratory of the department "G.Ciamician". Training in the interpretation of laboratory data and in writing laboratory report will be arranged.

Office hours

See the website of Daria Giacomini