Abstract
The ORCHESTRA project provides an innovative approach to learn from the SARS-CoV-2 health crisis and derive recommendations for increasing preparedness for future outbreaks. The main outcome of the project is the creation of a new pan-European cohort built on existing and new large-scale population cohorts in European and non-European countries. Data analysis through a federated learning technique supported by advanced modelling capabilities will allow the integration of epidemiological, clinical, microbiological and genotypic aspects of population-based cohorts with environment and socioeconomic features. The ORCHESTRA cohort will include SARS-CoV-2 infected and non-infected individuals of all ages and conditions and thereby enabling a retrospective evaluation of risk factors for the disease acquisition and progression of the disease and prospective follow-up aimed at exploring long-term consequences and analysis of vaccination response when vaccines will be available. To better address these research questions, the ORCHESTRA-cohort will include adequately sampled representatives of general populations, COVID-19 patients and special ‘at risk’ populations of fragile individuals and health-care workers. The project will assess also health costs of COVID-19 with special emphasis on delayed health services in the fragile populations. The participation of non-European and Low-Medium Income Countries and a Global COVID-19 Guidance group of major stakeholders and investigators from successful clinical trials addressing therapeutic approaches to COVID-19, ensures inclusion of all expertise needed and translation of recommendations to different social and economic settings. The project will significantly impact on the responsiveness to SARS-CoV-2 and can be used as a model for responsiveness for new public health threats.
Project details
Unibo Team Leader: Pierluigi Viale
Unibo involved Department/s:
Dipartimento di Scienze Mediche e Chirurgiche
Dipartimento di Scienze Biomediche e Neuromotorie
Coordinator:
Università degli Studi di VERONA(Italy)
Other Participants:
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh
(Germany)
Regional Authority of Public Health Banská Bystrica
(Slovak Republic)
Universitaet Zu Koeln
(Germany)
ALMA MATER STUDIORUM - Università di Bologna
(Italy)
Cineca - Consorzio Interuniversitario
(Italy)
Luxembourg Institute Of Health
(Luxembourg)
Universidad De Buenos Aires
(Argentina)
Universiteit Antwerpen
(Belgium)
Assistance Publique - Hopitaux De Paris
(France)
Institutul National De Sanatate Publica
(Romania)
Universidad De Oviedo
(Spain)
Fundacion Privada Instituto De Salud Global Barcelona
(Spain)
Centre de Recherches Medicales de Lambaréné-CERMEL
(Gabon)
Regione Emilia-Romagna
(Italy)
Inserm
(France)
Academisch Ziekenhuis Groningen
(Netherlands)
Universiteit Stuttgart
(Germany)
Charite' Universitatsmedizin Berlin
(Germany)
Ludwig-Maximilians-Universitat Munchen (Lmu)
(Germany)
Regione Veneto
(Italy)
Fondazione Penta ONLUS
(Italy)
Servicio Andaluz De Salud
(Spain)
Fondation Congolaise Pour La Recherche Medicale-Fcrm
(Congo, Republic of the)
Centre Informatique National De L'Enseignement Superieur-Cines
(France)
Apotheke l Universitätsklinikum Heidelberg, Germania
(Germany)
Total Eu Contribution: Euro (EUR) 27.887.638,18
Project Duration in months: 36
Start Date:
01/12/2020
End Date:
30/11/2023