Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic: ORCHESTRA


The ORCHESTRA project provides an innovative approach to learn from the SARS-CoV-2 health crisis and derive recommendations for increasing preparedness for future outbreaks. The main outcome of the project is the creation of a new pan-European cohort built on existing and new large-scale population cohorts in European and non-European countries. Data analysis through a federated learning technique supported by advanced modelling capabilities will allow the integration of epidemiological, clinical, microbiological and genotypic aspects of population-based cohorts with environment and socioeconomic features. The ORCHESTRA cohort will include SARS-CoV-2 infected and non-infected individuals of all ages and conditions and thereby enabling a retrospective evaluation of risk factors for the disease acquisition and progression of the disease and prospective follow-up aimed at exploring long-term consequences and analysis of vaccination response when vaccines will be available. To better address these research questions, the ORCHESTRA-cohort will include adequately sampled representatives of general populations, COVID-19 patients and special ‘at risk’ populations of fragile individuals and health-care workers. The project will assess also health costs of COVID-19 with special emphasis on delayed health services in the fragile populations. The participation of non-European and Low-Medium Income Countries and a Global COVID-19 Guidance group of major stakeholders and investigators from successful clinical trials addressing therapeutic approaches to COVID-19, ensures inclusion of all expertise needed and translation of recommendations to different social and economic settings. The project will significantly impact on the responsiveness to SARS-CoV-2 and can be used as a model for responsiveness for new public health threats.

Project details

Unibo Team Leader: Pierluigi Viale

Unibo involved Department/s:
Dipartimento di Scienze Mediche e Chirurgiche
Dipartimento di Scienze Biomediche e Neuromotorie

Università  degli Studi di VERONA(Italy)

Other Participants:
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh (Germany)
Regional Authority of Public Health Banská Bystrica (Slovak Republic)
Universitaet Zu Koeln (Germany)
ALMA MATER STUDIORUM - Università di Bologna (Italy)
Cineca - Consorzio Interuniversitario (Italy)
Luxembourg Institute Of Health (Luxembourg)
Universidad De Buenos Aires (Argentina)
Universiteit Antwerpen (Belgium)
Assistance Publique - Hopitaux De Paris (France)
Institutul National De Sanatate Publica (Romania)
Universidad De Oviedo (Spain)
Fundacion Privada Instituto De Salud Global Barcelona (Spain)
Centre de Recherches Medicales de Lambaréné-CERMEL (Gabon)
Regione Emilia-Romagna (Italy)
Inserm (France)
Academisch Ziekenhuis Groningen (Netherlands)
Universiteit Stuttgart (Germany)
Charite' Universitatsmedizin Berlin (Germany)
Ludwig-Maximilians-Universitat Munchen (Lmu) (Germany)
Regione Veneto (Italy)
Fondazione Penta ONLUS (Italy)
Servicio Andaluz De Salud (Spain)
Fondation Congolaise Pour La Recherche Medicale-Fcrm (Congo, Republic of the)
Centre Informatique National De L'Enseignement Superieur-Cines (France)
Apotheke l Universitätsklinikum Heidelberg, Germania (Germany)

Total Eu Contribution: Euro (EUR) 27.887.638,18
Project Duration in months: 36
Start Date: 01/12/2020
End Date: 30/11/2023

Cordis webpage
Project website

Good health and well-being This project contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016167 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016167