Plasma Sterilization Method

The proposed technology is able to sterilize bulk or pre-packaged items in blisters, through the indirect action of a non-thermal plasma. The invention claims to be an alternative to other existing methods of sterilization, e.g. using ethylene oxide (EtO).

Thematic area Biomedical
Ownership Alma Mater Studiorum – Università of Bologna
Inventors Gabriele Neretti, Paolo Seri, Carlo Angelo Borghi
Protection Italy
Licensing status Available for licensing agreement
Keywords Plasma, Sterilization, Packaging, EtO
Filed on Jun 07, 2018

In order to provde an alternative solution to the sterilization with EtO, having some drawbacks. the new method is based on the usage of either air present in the environment or synthetic air stored in gas cylinders, The air is delivered into a reactor in which an electrical discharge is generated, producing reactive oxygen and nitrogen species, namely ROS and RNS. The output is introduced into a vacuum chamber where the item to be sterilized is placed. The vacuum is achiedved in the sterilization chamber, ROS and RNS can be introduced. This process allows active species to penetrate inside the conventional semiporous blisters used in the medical field, achieving the sterilization of the contaited product


  • Sterilization of single-use accessories;
  • Biomedical field.



  • Greater sustainability of the process: no usage of polluting /toxic gases;
  • Low impact on the production site: no extra investments for its retrofit;
  • Lower production costs: no need for hazardous gas management;
  • No harmful chemical traces in the final product.