Plasma Sterilization Method

The proposed technology is able to sterilize bulk or pre-packaged items in blisters, through the indirect action of a non-thermal plasma. The invention claims to be an alternative to other existing methods of sterilization, e.g. using ethylene oxide (EtO).

Title of the patent Plasma Sterilization Method
Thematic area Biomedical
Ownership Alma Mater Studiorum – University of Bologna
Inventors Carlo Angelo Borghi, Gabriele Neretti, Paolo Seri
Protection International
Licensing status Available for licensing agreements
Keywords Plasma, Sterilization, Packaging, EtO
Filed on Jun 07, 2018

In order to provide an alternative solution to the sterilization with EtO, having some drawbacks. the new method is based on the usage of either air present in the environment or synthetic air stored in gas cylinders, The air is delivered into a reactor in which an electrical discharge is generated, producing reactive oxygen and nitrogen species, namely ROS and RNS. The output is introduced into a vacuum chamber where the item to be sterilized is placed. The vacuum is achiedved in the sterilization chamber, ROS and RNS can be introduced. This process allows active species to penetrate inside the conventional semiporous blisters used in the medical field, achieving the sterilization of the contaited product


  • Sterilization of single-use devices;
  • Biomedical field.



  • Greater sustainability of the process: no usage of polluting /toxic gases;
  • Low impact on the production site;
  • No harmful chemical traces in the final product.