Molecular signature

The invention relates to a method for determining a peripheral T-cell lymphoma (PTCL), in particular for subtyping PTCLs with a clinically significant diagnostic accuracy, based on the use of a molecular signature.

Title of the patent Molecular signature and its uses as diagnostic agent
Thematic area Pharmaceutical
Ownership Alma Mater Studiorum - Università di Bologna
Inventors Pier Paolo Piccaluga, Stefano Pileri, Claudio Agostinelli, Antonio De Leo, Fabio Fuligni, Anna Gazzola, Maria Antonella Laginestra, Maura Rossi
Protection Italy
Licensing status Available for licensing agreement
Keywords Peripheral T-cell lymphoma, gene expression profiling, molecular signature, diagnostic, differential diagnosis
Filed on Apr 09, 2013

Peripheral T-cell lymphomas are very aggressive tumours and their diagnosis is particularly difficult. Nevertheless, a prompt and correct diagnosis is essential for an optimal patients prognostication and treatment.

Molecular signatures specific of the commonest nodal PTCLs were identified. Testing them in a diagnostic accuracy study developed according to the Evidence Based Medicine rules, their efficiency in discriminating the different tumour types was demonstrated.

- Improvement of the diagnostic accuracy for PTCL differential diagnosis;

- relatively easy tool;

- reproducibility and possibility of standardization among different laboratories.