39286 - Systemic Clinical Biochemistry

Academic Year 2021/2022

  • Teaching Mode: Traditional lectures
  • Campus: Bologna
  • Corso: First cycle degree programme (L) in Biomedical Laboratory techniques (cod. 8484)

Learning outcomes

The student will achivea a detailed knowledge of the regulation of the biochemical processes in different tissues (liver, muscle, brain) together with ageneraloverview ofthe main biochemical deficitsgenerating metabolic diseasesin different tissues.

Course contents

Sistematic Biochemistry

Liver. Functions and metabolic flexibility. Bile acids. Glucidic metabolism. Lipid metabolism. Protein metabolism. Detossification of xenobiotics. Protection from Oxidative damage. Ethanol metabolism.

Muscle. Contractile and regulatory proteins. Muscle contraction. Ionic channel. Calcium fluxes. Skeletal and cardiac muscle metabolism. Bioenergetics: system of energy buffers "phosphocreatine shuttle" model.

Advanced noninvasive diagnostic techniques.

Physical principles of nuclear magnetic resonace spectroscopy (NMR). NMR application in in vivo biochemistry. Integration between holistic and reductionist approaches. In vivo 31P spectroscopy in brain and skeletal muscle (31P MRS).

Readings/Bibliography

Biochimica Sistematica Umana

C.M. Caldarera

CLUEB

Fondamenti di Biochimica

D. Voet

J. Voet

C. W. Pratt

ZANICHELLI

Teaching methods

Frontal lessons and calssroom exercises

Assessment methods

Written test with multiple choice questions

Teaching tools

Teaching material such as slides, animations, films used during lessons will be made available to studens on line. The printable material should be taken by the student to class.

The teaching material can be dowloaded at http://campus.unibo.it/

Username and password are assigned to students regularly registered atthe University of Bologna

Office hours

See the website of Emil Malucelli