13880 - Pharmacology and Pharmacotherapy

Learning outcomes

Learning outcomes will be the most important knowledge of natural, sinthetic and biotechnologic drugs both at experimental (pharmacokinetic, pharmacodynamic, adverse effects) and at clinical level. To this aim the student will know the drug doses and the most important therapeutic strategies, including the drug associations, and the therapeutic contraindications; the student will be able to evaluate the risk/benefit and cost/benefit ratios of a drug therapy.

Course contents

Course I - Pharmacology and Pharmacotherapy I (Prof. Andrea Tarozzi - 88 hours)

Course II - Chemotherapy (Prof.ssa Eleonora Turrini - 24 hours)

Course III - Pharmacovigilance (Prof.ssa Fabiana Morroni - 16 hours)

 

 

Course I - Pharmacology and Pharmacotherapy

NERVOUS SYSTEM PHARMACOLOGY

Drugs acting at synaptic and neuroeffector junctional sites

- Cholinergic agonists

- Anticholinesterase agents

- Antimuscarinic agents

- Adrenergic receptor agonists and antagonists

Drug acting on the central nervous system

- Antipsychotic drugs

- Drugs for the treatment of anxiety and insomnia disorders

- Agents for the treatment of affective disorders

- Drugs effective in the therapy of the epilepsies

- Drugs effective in the therapy of neurodegenerative acute diseases (stroke), chronic diseases (Parkinson's disease and Alzheimer's disease) e rare diseases (Huntington's disease, Amyotrophic Lateral Sclerosis)

- Drug dependence and addiction

Treatment of pain

- Opioid analgesics and antagonists

- Non-opioid analgesics

General (brief mentioning) and local anesthetics

Drugs for treatment of primary headache

PHARMACOLOGY OF THE CARDIOVASCULAR SYSTEM

- Drug therapy for atherosclerosis

- Antihypertensive agents

- Antihypotensive agents and shock

- Agents used in the treatment of heart failure

- Antiarrhythmic agents

- Drugs used for the treatment of angina pectoris

- Pharmacological treatment of vascular diseases

RENAL FUNCTION PHARMACOLOGY

- Diuretics and other drugs for edema

- Agents affecting the renal conservation of water

PHARMACOLOGY OF HEMATOPOIETIC SYSTEM

- Anti-anemic agents

- Antiplatelet agents

- Coagulant and anticoagulant agents

- Thrombolytic and antithrombolytic agents

PHARMACOLOGY OF RESPIRATORY SYSTEM

- Cough suppressants, expectorans, mucolytics

- Drugs used in treatment of asthma

PHARMACOLOGY OF GASTROINTESTINAL SYSTEM

- Agents used for control of gastric acidity and treatment of peptic ulcers

- Emetic and antiemetic agents

- Prokinetic agents

- Agents used for constipation

- Agents used for diarrhea and inflammatory bowel disease

- Agents used for biliary and pancreatic disease

DRUG THERAPY OF INFLAMMATION

- Nonsteroidal anti-inflammatory drugs (nsaids)

- Steroidal anti-inflammatory drugs

- Disease-modifying antirheumatic drugs (dmards)

- Drugs used in the treatment of gout

- Antihistamines

ENDROCRINE PHARMACOLOGY

- Oral hypoglycemic agents and the pharmacology of the endocrine pancreas

- Thyroid hormones and antithyroid drugs

- Adrenocorticotropic hormone; corticosteroids and their synthetic analogs; inibitors of the synthesis and actions of corticosteroids

- Reproductive hormone, estrogens and progestins, contraceptive drugs, androgens

- Hormones and agents affecting calcification and bone turnover

- Pharmacological therapy for obesity

Course II - Chemotherapy

- Introduction

Microbial diseases

- Antimicrobial agents: penicillins, cephalosporins and other b-lactam compounds; macrolides, ketolides and lincosamides; aminoglycosides; fluoroquinolones; glycopeptides; amphenicols; tetracyclines; rifamycins; sulfonamides e pyrimidines; drugs for tuberculosis.

- Antifungal agents

- Antiviral agents

Parasitic infections

- Antiprotozoal agents: malaria; leishmaniasis; amebiasis, giardiasis and trichomoniasis; toxoplasmosis; trypanosomiasis.

- Anthelmintic agents

- Ectoparasiticides

Neoplastic disorders

- Alkylating agents

- Antimetabolites agents

- Topoisomerase inhibitors

- Microtubule inhibitors

- Hormone antagonists

- Other signal transduction inhibitors and cytotoxic antibodies

Course III - Pharmacovigilance

- Pre-clinical and clinical trials of drugs. Specificity of clinical trials in the pediatric field. Ethics committees: normative and ethical aspects.

- Principles of Pharmacoepidemiology.

- Fundamentals of Pharmacovigilance. Definitions and classification of adverse reactions (ADR). Methods in Pharmacovigilance. National Network and New European Regulations.

- Elements of Pharmacoeconomics.

Readings/Bibliography

1. ROSSI F., V. CUOMO, C. RICCARDI (a cura di) "Farmacologia. Principi di base e applicazioni terapeutiche", III ed., Torino, Edizioni Minerva Medica, 2016.

2. KATZUNG B.G. "Farmacologia Generale e Clinica", X ed. it. Piccin Editore, 2017.

   

Teaching methods

Lectures

Assessment methods

Final examination is oral. Will be required to treat four subjects regarding:

1. Chemiotherapy (3 CFU) (if the result of the test of chemotherapy is positive, this questioncan be excluded)

2. Nervous system pahrmacology (3 CFU)

3. Pharmacology of the cardiovascular andhematopoieticsystem, and of renal function (4 CFU)

4. Pharmacology of the respiratory andgastrointestinalsystem; drug therapy on inflammation and endocrine system pharmacology (3 CFU) and Pharmacovigilance (3 CFU)

Teaching tools

PC

Slides

Overhead projector

Students can find slides regarding the course material usedby teacher during thelessonson Alma Campus.

Office hours

See the website of Andrea Tarozzi

See the website of Eleonora Turrini

See the website of Fabiana Morroni