12946 - Molecular Biology (L-Z)

Academic Year 2017/2018

  • Teaching Mode: Traditional lectures
  • Campus: Bologna
  • Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)

Learning outcomes

At the end of the Course, the Student will be able to discuss a number of crucial issues in cellular and molecular biology, including: the nuclear trafficking of signaling molecules and transcription factors; the main pathways of transcription factor activation; the molecular underpinning of gene expression regulation; the role of epigenetics and chromatin remodeling in cell fate determination; the current molecular dissection of stem cell pluripotency; the current understanding of cell reprogramming; a brief overview of the entanglement between Physics and Biology.

Course contents

- The cytoskeleton as a dynamic web-like entity supporting the network of intracellular signaling - Analysis of the interplay between signal-transduction pathways and gene expression - Nuclear trafficking of signaling molecules and transcription factors; transcriptional implications - Genome structure and fucntion - Epigenetics, chromatin remodeling and physical forces driving DNA architecture and gene transcription - Genome and differentiating potential - Stem Cells and perspectives for Regenerative Medicine - Cell Reprogramming: perspectives in cell therapy

Readings/Bibliography

Based on the continuously evolving of the field and the lack of comprehensive and exhaustive material in the form of books, the course is based on the presentation of the material that will be supplied to the students

Teaching methods

Presentation and informal discussion of the scientific material

Assessment methods

Timely discussion of the investigate issues: final oral examination

Teaching tools

Lessons and seminars conducted wit power point presentations

Office hours

See the website of Carlo Ventura