The vision of I-ONE is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will:
(a) Have long-term stability associated to high biocompatibility and safety.
(b) Have reduced risk of a host versus graft immune response.
(c) Mimic the local microenvironment for stem/precursor cell recruitment and differentiation. (d) Monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies.
(e) Perform local stimulation with tunable electric fields.
(f) Deliver locally growth factors, neurotransmitters, and drugs.
The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nano-particle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response. The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the I-ONE device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogenous stem cells by implanting the I-ONE device into a contusion SCI animal model. I-ONE will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.
Coordinator
Consiglio Nazionale Delle Ricerche –CNR (Italy)
Other participants
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA
- Dip. di Chimica "G. Ciamician"
- Resp. Scientifico: Prof. Francesco Zerbetto
Centre National De La Recherche Scientifique - CNRS (France)
Stmicroelectronics Srl (Italy)
Linkopings Universitet (Sweden)
Agencia Estatal Consejo Superior De Investigaciones Cientificas (Spain)
The Chancellor, Masters And Scholars Of The University Of Cambridge (UK)
Scriba Nanotecnologie Srl (Italy)
Universidade Do Algarve (Portugal)
Amires Sarl (Switzerland)
Polyganics Innovations Bv (Netherlands)
Start date 01/03/2012
End date 28/02/2015
Duration 36 months
Project Reference 280772
Project cost 5.138.535,20 EURO
Project Funding 3.834.336 EURO
Area FP7- COOPERATION – NMP
Subprogramme Area NMP.2011.1.4-4: Nanotechnology based implantable and interfaceable devices
Contract type Collaborative project