MARK-AGE

European Study to Establish Biomarkers of Human Ageing

Unibo Team Leader: Prof. Claudio Franceschi, Centro Interdipartimentale "Luigi Galvani"

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of biological age and predict the onset of age-related diseases and/or residual lifetime are termed biomarkers of ageing. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing.
We propose to conduct a population study (3,700 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (GEHA offspring) are expected to age at a slower rate.
They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the
study. A wide range of candidate biomarkers will be tested, including (a) "classical" ones for which data from several smaller studies have been published; (b) "new" ones, based on recent preliminary data, as well as (c) "novel" ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.

Coordinator UNIVERSITAET KONSTANZ (Germany)
Other participants
TAMPEREEN YLIOPISTO (Finland)
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (UK)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (The Netherlands)
AARHUS UNIVERSITET (Denmark)
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM MARCELEGO NENCKIGO POLSKIEJ ACA NAUK (Poland)
ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM (The Netherlands)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (Spain)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA (The Netherlands)
VIB (Belgium)
UNIVERSITAET HOHENHEIM (Germany)
STRATICELL SCREENING TECHNOLOGIES (Belgium)
DNAGE BV (The Netherlands)
BIOTESYS GMBH (Germany)
INSTITUTUL NATIONAL DE GERONTOLOGIE I GERIATRIE ANA ASLAN (Rumania)
ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA(Italy)
NESTEC S.A (Svizzera)
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN (Austria)
ASTON UNIVERSITY (UK)
MARTIN-LUTHER-UNIVERSITAET HALLE WITTENBERG (Germany)
UNILEVER UK CENTRAL RESOURCES LIMITED (UK)
UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (Italy)
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA

  • Centro Interdipartimentale "Luigi Galvani"
  • Resp. Scientifico : Prof. Claudio Franceschi

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (France)
FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR (Belgium)
NATIONAL HELLENIC RESEARCH FOUNDATION (Greece)

 

Start date 01/04/2008

End date 31/03/2013

Duration 60 monthes

Project cost 15896268 Euro

Project Funding 11989327 Euro

Subprogramme Area Biomarkers of ageing

Contract type Large-scale integrating project