Curriculum Vitae
Principal Investigator/Program Director:
Brandimarti, Renato
BIOGRAPHICAL SKETCH
NAME
Brandimarti, Renato
POSITION TITLE
Assistant Professor of Microbiology
eRA COMMONS USER NAME
Brandimarti
EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
University of Bologna, Italy
Science Dr
1988
Biology
University of Bologna, Italy
PhD
1993
Cell Biology andPhysiol.
A.
Positions and Honors.
Post-doctoral education
1993-1995
AIDS fellowship. University
of Chicago, Dept. of Molecular Genetics and Cellular
Biology.
Positions and Employment
1995-1998
Research Associate
. University of Chicago, Dept. of Molecular Genetics and Cellular
Biology.
1998-1999
Research Associate - Instructor. University of
Chicago, Dept. of Molecular Genetics and Cellular
Biology.
2000-
Assistant Professor of Microbiology
, University of Bologna
Other Experience and Collaborations
Summer 2000 Visiting Researcher. The
Marjorie B. Kovler Viral Oncology Laboratories,
Department
(2 months) of Molecular Genetics and
Cellular Biology, University of Chicago, Illinois. USA.
Summer 2001 Visiting
Researcher. Department of Pharmacology and Physiology, School
of
(3 months) Medicine, MCP Hanhemann
University, Philadelphia, PA. Usa.
Summer 2002 Visiting
Researcher. Department of Pharmacology and Physiology, School
of
(3 months) Medicine, Drexel University,
Philadelphia, PA. USA.
Summer 2003Visiting
Researcher. Department of Pharmacology and Physiology, School
of
(2 months) Medicine, Drexel University,
Philadelphia, PA. USA.
Summer 2005Visiting
Researcher. Department of Pharmacology and Physiology, School
of
(4 months) Medicine, Drexel University,
Philadelphia, PA. USA.
Spring 2007 Visiting Researcher. Department of Pharmacology and
Physiology, School of
(4 months) Medicine, Drexel University,
Philadelphia, PA. USA.
B.
Selected peer-reviewed publications (in chronological
order).
Khan MZ, Brandimarti R, Shimizu S, Nicolai J, Crowe E, Meucci
O
.The chemokine CXCL12 promotes survival of postmitotic neurons by
regulating Rb protein. Cell
Death Differ. 2008.
15(10):1663-72.
LaVail JH, Tauscher AN, Sucher A, Harrabi O, Brandimarti
R.Viral
regulation of the long distance axonal transport of herpes simplex
virus nucleocapsid.
Neuroscience. 2007; 146(3):974-85.
Khan MZ, Shimizu
S, Patel JP, Nelson A, Le MT, Mullen-Przeworski A, Brandimarti R,
Fatatis A, Meucci O.
Regulation of neuronal P53 activity by CXCR 4.
Mol Cell Neurosci. 2005;30(1):58-66.
Khan, M.Z., Brandimarti, R., Patel,
J.,
HUYNH,N., WANG, J.,HUANG, Z., FATATIS, A., and MEUCCI, O. Apoptotic
and Antiapoptotic Effects of CXCR4: Is It a Matter of Intrinsic
Efficacy? Implications for HIV Neuropathogenesis. AIDS Research
and Human Retroviruses. 2004; 20(10): 1063-71.
BRANDIMARTI, R., KHAN, M.Z., MUSSER, B.J., RESUE, D.M., FATATIS,
A.,
a
nd O.MEUCCI.
Regulation of celle cycle proteins by chemokine receptors: a novel
pathway in HIV pathogenesis?
J Neurovirol. 2004;10 Suppl 1:108-12
.
.
KHAN, M.Z., BRANDIMARTI, R., MUSSER, B.J., RESUE, D.M., FATATIS,
A.,
and O. MEUCCI. The
chemokine receptor CXCR4 regulates cell cycle proteins in neurons.
J Neurovirol. Jun;9(3):300-14.
2003.
BRANDIMARTI, R., KHAN, M.Z., MUSSER, B.J., RESUE, D.M., FATATIS,
A.,
and O.
MEUCCI.
Chemokine receptors and HIV-induced neurodegeneration: are cell
cycle proteins involved? Abstract published in J
Neurovirol. 8 (Suppl.1):26. 2002.
GALVAN, V., BRANDIMARTI, R., MUNGER, J.,
and B. ROIZMAN.
Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by
herpes simplex virus 1 infection in HEp-2 cells. J
Virol. 74:1931-8, 2000.
ADVANI, S.J., BRANDIMARTI, R., WEICHSELBAUM, R.R.,
and B. ROIZMAN. The
disappearance of cyclins A and B and the increase in activity of
the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus
1-infected cells require expression of the alpha22/U(S)1.5 and
U(L)13 viral genes. J Virol. 74:8-15,
2000.
GALVAN, V., BRANDIMARTI, R.,
and B. ROIZMAN.
Herpes simplex virus 1 blocks caspase-3-independent and
caspase-dependent pathways to cell death.
J Virol. 73:3219-26,1999.
BRANDIMARTI, R., and B. ROIZMAN. U
S
9, a stable lysine-less herpes simplex virus 1 protein, is
ubiquitinated prior to packaging into virions, and associates with
proteasomes. Proc. Natl. Acad. Sci. USA,
94:13973-13978, 1997.
HE, B., CHOU, J., BRANDIMARTI, R., MOHR, J., GLUZMAN, Y., and
ROIZMAN, B. Suppression of the phenotype of ã
134.5
-
herpes simplex virus 1: failure of activated RNA-dependent protein
kinase to shut off protein synthesis is associated with a deletion
in the domain of the a
47 gene. J. Virol., 71:6049-54, 1997.
BRANDIMARTI, R., HUANG, T., ROIZMAN, B., and CAMPADELLI FIUME, G.,
Mapping of Herpes Simplex Virus 1 genes with mutationes which
overcome host restrictions to infection. Proc. Natl.
Acad. Sci. USA, 91:5406-5410, 1994.
VAN GENDEREN, I.L., BRANDIMARTI, R., TORRISI, M.R., CAMPADELLI, G.,
and VAN MEER, G., The phospholipid composition of extracellular
herpes simplex virions differs from that of host cell nuclei. Virology, 200:831-836, 1994.
CAMPADELLI, G., BRANDIMARTI, R., DI LAZZARO, C., WARD, P.L.,
ROIZMAN, B., and TORRISI, R., Fragmentation and dispersal of Golgi
proteins and redistribution of Glycoproteins and glycolipids
processed through the Golgi apparatus after infection with herpes
simplex virus. Proc. Natl. Acad. Sci. USA,
90:2798-2802, 1993.
C.
Research Support.
Ongoing Research
Support
Pallotti Foundation 2007-2008. Brandimarti, Renato (PI)
Role of cks1 in cell cycle progression and cell proliferation
control.
Role: PI
RFO Grants – University of Bologna. 2007-2008. Brandimarti, Renato
(PI)
Role of cks1 in cell cycle progression and cell proliferation
control.
Role: PI
Completed Research
Support
1R01-DA15014-01. 2001-2006. Olimpia Meucci (PI)
Role of chemokine receptors in neuronal survival
Role: co-investigator
RFO Grants – University of Bologna. 2002-2004. (PI)
Post-translational modifications and localization of US9 protein of
Herpes Simplex Virus 1.
Role: PI
RFO Grants – University of Bologna. 2005-2007. Hochkoeppler,
Alejandro (PI)
Transcriptional regulation of cks1 expression in yeast.
Role: co-investigator
Young scientists Grants– University of Bologna. 2001.
(PI)
Analysis of localization of a US9-gfp chimaeric protein of Herpes
Simplex Virus 1.
Role: PI